TY  - JOUR
AU  - Lopes, Leonor
AU  - Jiao, Fangyang
AU  - Xue, Song
AU  - Pyka, Thomas
AU  - Krieger, Korbinian
AU  - Ge, Jingjie
AU  - Xu, Qian
AU  - Fahmi, Rachid
AU  - Spottiswoode, Bruce
AU  - Soliman, Ahmed
AU  - Buchert, Ralph
AU  - Brendel, Matthias
AU  - Hong, Jimin
AU  - Guan, Yihui
AU  - Bassetti, Claudio L A
AU  - Rominger, Axel
AU  - Zuo, Chuantao
AU  - Shi, Kuangyu
AU  - Wu, Ping
TI  - Dopaminergic PET to SPECT domain adaptation: a cycle GAN translation approach.
JO  - European journal of nuclear medicine and molecular imaging
VL  - 52
IS  - 3
SN  - 1619-7070
CY  - Heidelberg [u.a.]
PB  - Springer-Verl.
M1  - DZNE-2025-00229
SP  - 851 - 863
PY  - 2025
AB  - Dopamine transporter imaging is routinely used in Parkinson's disease (PD) and atypical parkinsonian syndromes (APS) diagnosis. While [11C]CFT PET is prevalent in Asia with a large APS database, Europe relies on [123I]FP-CIT SPECT with limited APS data. Our aim was to develop a deep learning-based method to convert [11C]CFT PET images to [123I]FP-CIT SPECT images, facilitating multicenter studies and overcoming data scarcity to promote Artificial Intelligence (AI) advancements.A CycleGAN was trained on [11C]CFT PET (n = 602, 72
KW  - Humans
KW  - Tomography, Emission-Computed, Single-Photon: methods
KW  - Positron-Emission Tomography: methods
KW  - Parkinson Disease: diagnostic imaging
KW  - Parkinson Disease: metabolism
KW  - Image Processing, Computer-Assisted: methods
KW  - Male
KW  - Female
KW  - Dopamine: metabolism
KW  - Deep Learning
KW  - Middle Aged
KW  - Dopamine Plasma Membrane Transport Proteins: metabolism
KW  - Aged
KW  - Tropanes
KW  - CFT PET (Other)
KW  - Cycle GAN (Other)
KW  - Domain adaptation (Other)
KW  - FP-CIT SPECT (Other)
KW  - Parkinson’s disease (Other)
KW  - Dopamine (NLM Chemicals)
KW  - Dopamine Plasma Membrane Transport Proteins (NLM Chemicals)
KW  - 2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane (NLM Chemicals)
KW  - Tropanes (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39557690
DO  - DOI:10.1007/s00259-024-06961-x
UR  - https://pub.dzne.de/record/276157
ER  -