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000276159 1001_ $$00000-0002-6389-5054$$aHaeusler, Karl Georg$$b0
000276159 245__ $$aExcessive Supraventricular Ectopic Activity in Patients With Acute Ischemic Stroke Is Associated With Atrial Fibrillation Detection Within 24 Months After Stroke: A Predefined Analysis of the MonDAFIS Study.
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000276159 520__ $$aExcessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection.The investigator-initiated, prospective, open, multicenter MonDAFIS (Impact of Standardized Monitoring for Detection of Atrial Fibrillation in Ischemic Stroke) study randomized 3465 patients with acute ischemic stroke without known AF 1:1 to usual diagnostic procedures for AF detection or additive Holter monitoring in hospital for up to 7 days, analyzed in a core laboratory. Secondary study objectives include the comparison of recurrent stroke, myocardial infarction, major bleeding, and all-cause death within 24 months in patients with ESVEA (defined as ectopic supraventricular beats ≥480/day or atrial runs of 10-29 seconds or both) versus patients with newly diagnosed AF versus patients without ESVEA or AF (non-ESVEA/AF), randomized to the intervention group. Overall, 1435 (84.8%) of 1714 patients randomized to the intervention group had analyzable study ECG monitoring of at least 48 hours' duration within the first 72 hours of monitoring. ESVEA was detected in 363 (25.3%) patients, while AF was first detected in 48 (3.3%) patients. Within 24 months, AF was newly detected in 67 (18.5%) patients with ESVEA versus 60 (5.9%) patients without ESVEA/AF- (P<0.001). The composite outcome at 24 months was not different between patients with ESVEA and patients without ESVEA/AF (15.2% versus 12.6%; P=0.242). All-cause death was numerically higher in patients with ESVEA (6.6% versus 3.2%), but failed statistical significance (P=0.433) in multivariate analysis (including age, heart failure, stroke severity, and creatinine at baseline).ESVEA in the acute phase of ischemic stroke or transient ischemic attack is associated with AF detection during follow-up and therefore may be used to select patients for prolonged ECG monitoring.URL: https://www.clinicaltrials.gov; Unique identifier: NCT02204267.
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000276159 650_7 $$2Other$$aECG
000276159 650_7 $$2Other$$aatrial fibrillation
000276159 650_7 $$2Other$$aatrial run
000276159 650_7 $$2Other$$adeath
000276159 650_7 $$2Other$$astroke
000276159 650_7 $$2Other$$asupraventricular ectopy
000276159 650_2 $$2MeSH$$aHumans
000276159 650_2 $$2MeSH$$aAtrial Fibrillation: diagnosis
000276159 650_2 $$2MeSH$$aAtrial Fibrillation: physiopathology
000276159 650_2 $$2MeSH$$aAtrial Fibrillation: complications
000276159 650_2 $$2MeSH$$aFemale
000276159 650_2 $$2MeSH$$aMale
000276159 650_2 $$2MeSH$$aAged
000276159 650_2 $$2MeSH$$aIschemic Stroke: diagnosis
000276159 650_2 $$2MeSH$$aIschemic Stroke: mortality
000276159 650_2 $$2MeSH$$aIschemic Stroke: physiopathology
000276159 650_2 $$2MeSH$$aIschemic Stroke: etiology
000276159 650_2 $$2MeSH$$aElectrocardiography, Ambulatory: methods
000276159 650_2 $$2MeSH$$aProspective Studies
000276159 650_2 $$2MeSH$$aTime Factors
000276159 650_2 $$2MeSH$$aMiddle Aged
000276159 650_2 $$2MeSH$$aAtrial Premature Complexes: diagnosis
000276159 650_2 $$2MeSH$$aAtrial Premature Complexes: physiopathology
000276159 650_2 $$2MeSH$$aRecurrence
000276159 650_2 $$2MeSH$$aRisk Factors
000276159 650_2 $$2MeSH$$aAged, 80 and over
000276159 7001_ $$00000-0002-5057-7487$$aTütüncü, Serdar$$b1
000276159 7001_ $$aFiessler, Cornelia$$b2
000276159 7001_ $$00000-0001-6336-0327$$aJawad-Ul-Qamar, Muhammad$$b3
000276159 7001_ $$aKunze, Claudia$$b4
000276159 7001_ $$00000-0002-8743-3743$$aSchurig, Johannes$$b5
000276159 7001_ $$00000-0003-4739-4230$$aDietzel, Joanna$$b6
000276159 7001_ $$00000-0002-0310-5903$$aKrämer, Michael$$b7
000276159 7001_ $$0P:(DE-2719)2810273$$aPetzold, Gabor C$$b8$$udzne
000276159 7001_ $$00000-0002-0631-5711$$aRoyl, Georg$$b9
000276159 7001_ $$aHelberg, Torsten$$b10
000276159 7001_ $$00000-0002-4785-1449$$aThomalla, Götz$$b11
000276159 7001_ $$aNabavi, Darius G$$b12
000276159 7001_ $$00000-0002-8088-9991$$aRöther, Joachim$$b13
000276159 7001_ $$00000-0003-2620-9323$$aLaufs, Ulrich$$b14
000276159 7001_ $$00000-0002-0583-1300$$aVeltkamp, Roland$$b15
000276159 7001_ $$00000-0002-2681-3515$$aHeuschmann, Peter U$$b16
000276159 7001_ $$00000-0002-1881-0197$$aKirchhof, Paulus$$b17
000276159 7001_ $$00000-0001-8153-3025$$aOlma, Manuel C$$b18
000276159 7001_ $$0P:(DE-2719)2811033$$aEndres, Matthias$$b19$$eLast author
000276159 773__ $$0PERI:(DE-600)2653953-6$$a10.1161/JAHA.123.034512$$gVol. 14, no. 2, p. e034512$$n2$$pe034512$$tJournal of the American Heart Association$$v14$$x2047-9980$$y2025
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