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@ARTICLE{Haeusler:276159,
      author       = {Haeusler, Karl Georg and Tütüncü, Serdar and Fiessler,
                      Cornelia and Jawad-Ul-Qamar, Muhammad and Kunze, Claudia and
                      Schurig, Johannes and Dietzel, Joanna and Krämer, Michael
                      and Petzold, Gabor C and Royl, Georg and Helberg, Torsten
                      and Thomalla, Götz and Nabavi, Darius G and Röther,
                      Joachim and Laufs, Ulrich and Veltkamp, Roland and
                      Heuschmann, Peter U and Kirchhof, Paulus and Olma, Manuel C
                      and Endres, Matthias},
      title        = {{E}xcessive {S}upraventricular {E}ctopic {A}ctivity in
                      {P}atients {W}ith {A}cute {I}schemic {S}troke {I}s
                      {A}ssociated {W}ith {A}trial {F}ibrillation {D}etection
                      {W}ithin 24 {M}onths {A}fter {S}troke: {A} {P}redefined
                      {A}nalysis of the {M}on{DAFIS} {S}tudy.},
      journal      = {Journal of the American Heart Association},
      volume       = {14},
      number       = {2},
      issn         = {2047-9980},
      address      = {New York, NY},
      publisher    = {Association},
      reportid     = {DZNE-2025-00231},
      pages        = {e034512},
      year         = {2025},
      abstract     = {Excessive supraventricular ectopic activity (ESVEA) is
                      regarded as a risk marker for later atrial fibrillation (AF)
                      detection.The investigator-initiated, prospective, open,
                      multicenter MonDAFIS (Impact of Standardized Monitoring for
                      Detection of Atrial Fibrillation in Ischemic Stroke) study
                      randomized 3465 patients with acute ischemic stroke without
                      known AF 1:1 to usual diagnostic procedures for AF detection
                      or additive Holter monitoring in hospital for up to 7 days,
                      analyzed in a core laboratory. Secondary study objectives
                      include the comparison of recurrent stroke, myocardial
                      infarction, major bleeding, and all-cause death within 24
                      months in patients with ESVEA (defined as ectopic
                      supraventricular beats ≥480/day or atrial runs of 10-29
                      seconds or both) versus patients with newly diagnosed AF
                      versus patients without ESVEA or AF (non-ESVEA/AF),
                      randomized to the intervention group. Overall, 1435
                      $(84.8\%)$ of 1714 patients randomized to the intervention
                      group had analyzable study ECG monitoring of at least 48
                      hours' duration within the first 72 hours of monitoring.
                      ESVEA was detected in 363 $(25.3\%)$ patients, while AF was
                      first detected in 48 $(3.3\%)$ patients. Within 24 months,
                      AF was newly detected in 67 $(18.5\%)$ patients with ESVEA
                      versus 60 $(5.9\%)$ patients without ESVEA/AF- (P<0.001).
                      The composite outcome at 24 months was not different between
                      patients with ESVEA and patients without ESVEA/AF $(15.2\%$
                      versus $12.6\%;$ P=0.242). All-cause death was numerically
                      higher in patients with ESVEA $(6.6\%$ versus $3.2\%),$ but
                      failed statistical significance (P=0.433) in multivariate
                      analysis (including age, heart failure, stroke severity, and
                      creatinine at baseline).ESVEA in the acute phase of ischemic
                      stroke or transient ischemic attack is associated with AF
                      detection during follow-up and therefore may be used to
                      select patients for prolonged ECG monitoring.URL:
                      https://www.clinicaltrials.gov; Unique identifier:
                      NCT02204267.},
      keywords     = {Humans / Atrial Fibrillation: diagnosis / Atrial
                      Fibrillation: physiopathology / Atrial Fibrillation:
                      complications / Female / Male / Aged / Ischemic Stroke:
                      diagnosis / Ischemic Stroke: mortality / Ischemic Stroke:
                      physiopathology / Ischemic Stroke: etiology /
                      Electrocardiography, Ambulatory: methods / Prospective
                      Studies / Time Factors / Middle Aged / Atrial Premature
                      Complexes: diagnosis / Atrial Premature Complexes:
                      physiopathology / Recurrence / Risk Factors / Aged, 80 and
                      over / ECG (Other) / atrial fibrillation (Other) / atrial
                      run (Other) / death (Other) / stroke (Other) /
                      supraventricular ectopy (Other)},
      cin          = {AG Endres / AG Petzold / Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1811005 / I:(DE-2719)1013020 /
                      I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39791425},
      doi          = {10.1161/JAHA.123.034512},
      url          = {https://pub.dzne.de/record/276159},
}