%0 Journal Article
%A Liampas, Ioannis
%A Siokas, Vasileios
%A Mourtzi, Niki
%A Charisis, Sokratis
%A Sampatakakis, Stefanos N
%A Foukarakis, Ioannis
%A Hatzimanolis, Alex
%A Ramirez, Alfredo
%A Lambert, Jean-Charles
%A Yannakoulia, Mary
%A Kosmidis, Mary H
%A Dardiotis, Efthimios
%A Hadjigeorgiou, Georgios M
%A Sakka, Paraskevi
%A Rouskas, Konstantinos
%A Scarmeas, Nikolaos
%T Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia.
%J Geriatrics
%V 10
%N 1
%@ 2308-3417
%C Basel
%I MDPI
%M DZNE-2025-00249
%P 14
%D 2025
%X There is a paucity of evidence on the association between genetic propensity for hippocampal atrophy with cognitive outcomes. Therefore, we examined the relationship of the polygenic risk score for hippocampal atrophy (PRShp) with the incidence of amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) as well as the rates of cognitive decline.Participants were drawn from the population-based HELIAD cohort. Comprehensive neuropsychological assessments were performed at baseline and at follow-up. PRShp was derived from the summary statistics of a large genome-wide association study for hippocampal volume. Cox proportional hazards models as well as generalized estimating equations (GEEs) were used to evaluate the association of PRShp with the combined incidence of aMCI/AD and cognitive changes over time, respectively. All models were adjusted for age, sex, education, and apolipoprotein E (APOE) genotype.Our analysis included 618 older adults, among whom 73 developed aMCI/AD after an average follow-up of 2.96 ± 0.8 years. Each additional SD of PRShp elevated the relative hazard for incident aMCI/AD by 46
%K Alzheimer’s disease (Other)
%K cognitive decline (Other)
%K hippocampal atrophy (Other)
%K polygenic risk score (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39846584
%R 10.3390/geriatrics10010014
%U https://pub.dzne.de/record/276181