TY  - JOUR
AU  - Liampas, Ioannis
AU  - Siokas, Vasileios
AU  - Mourtzi, Niki
AU  - Charisis, Sokratis
AU  - Sampatakakis, Stefanos N
AU  - Foukarakis, Ioannis
AU  - Hatzimanolis, Alex
AU  - Ramirez, Alfredo
AU  - Lambert, Jean-Charles
AU  - Yannakoulia, Mary
AU  - Kosmidis, Mary H
AU  - Dardiotis, Efthimios
AU  - Hadjigeorgiou, Georgios M
AU  - Sakka, Paraskevi
AU  - Rouskas, Konstantinos
AU  - Scarmeas, Nikolaos
TI  - Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer's Dementia.
JO  - Geriatrics
VL  - 10
IS  - 1
SN  - 2308-3417
CY  - Basel
PB  - MDPI
M1  - DZNE-2025-00249
SP  - 14
PY  - 2025
AB  - There is a paucity of evidence on the association between genetic propensity for hippocampal atrophy with cognitive outcomes. Therefore, we examined the relationship of the polygenic risk score for hippocampal atrophy (PRShp) with the incidence of amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) as well as the rates of cognitive decline.Participants were drawn from the population-based HELIAD cohort. Comprehensive neuropsychological assessments were performed at baseline and at follow-up. PRShp was derived from the summary statistics of a large genome-wide association study for hippocampal volume. Cox proportional hazards models as well as generalized estimating equations (GEEs) were used to evaluate the association of PRShp with the combined incidence of aMCI/AD and cognitive changes over time, respectively. All models were adjusted for age, sex, education, and apolipoprotein E (APOE) genotype.Our analysis included 618 older adults, among whom 73 developed aMCI/AD after an average follow-up of 2.96 ± 0.8 years. Each additional SD of PRShp elevated the relative hazard for incident aMCI/AD by 46
KW  - Alzheimer’s disease (Other)
KW  - cognitive decline (Other)
KW  - hippocampal atrophy (Other)
KW  - polygenic risk score (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39846584
DO  - DOI:10.3390/geriatrics10010014
UR  - https://pub.dzne.de/record/276181
ER  -