% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Liampas:276181,
      author       = {Liampas, Ioannis and Siokas, Vasileios and Mourtzi, Niki
                      and Charisis, Sokratis and Sampatakakis, Stefanos N and
                      Foukarakis, Ioannis and Hatzimanolis, Alex and Ramirez,
                      Alfredo and Lambert, Jean-Charles and Yannakoulia, Mary and
                      Kosmidis, Mary H and Dardiotis, Efthimios and Hadjigeorgiou,
                      Georgios M and Sakka, Paraskevi and Rouskas, Konstantinos
                      and Scarmeas, Nikolaos},
      title        = {{G}enetic {P}redisposition to {H}ippocampal {A}trophy and
                      {R}isk of {A}mnestic {M}ild {C}ognitive {I}mpairment and
                      {A}lzheimer's {D}ementia.},
      journal      = {Geriatrics},
      volume       = {10},
      number       = {1},
      issn         = {2308-3417},
      address      = {Basel},
      publisher    = {MDPI},
      reportid     = {DZNE-2025-00249},
      pages        = {14},
      year         = {2025},
      abstract     = {There is a paucity of evidence on the association between
                      genetic propensity for hippocampal atrophy with cognitive
                      outcomes. Therefore, we examined the relationship of the
                      polygenic risk score for hippocampal atrophy (PRShp) with
                      the incidence of amnestic mild cognitive impairment (aMCI)
                      and Alzheimer's disease (AD) as well as the rates of
                      cognitive decline.Participants were drawn from the
                      population-based HELIAD cohort. Comprehensive
                      neuropsychological assessments were performed at baseline
                      and at follow-up. PRShp was derived from the summary
                      statistics of a large genome-wide association study for
                      hippocampal volume. Cox proportional hazards models as well
                      as generalized estimating equations (GEEs) were used to
                      evaluate the association of PRShp with the combined
                      incidence of aMCI/AD and cognitive changes over time,
                      respectively. All models were adjusted for age, sex,
                      education, and apolipoprotein E (APOE) genotype.Our analysis
                      included 618 older adults, among whom 73 developed aMCI/AD
                      after an average follow-up of 2.96 ± 0.8 years. Each
                      additional SD of PRShp elevated the relative hazard for
                      incident aMCI/AD by $46\%.$ Participants at the top quartile
                      of PRShp had an almost three times higher risk of converting
                      to aMCI/AD compared to the lowest quartile group. Higher
                      PRShp scores were also linked to steeper global cognitive
                      and memory decline. The impact of PRShp was greater among
                      women and younger adults.Our findings support the
                      association of PRShp with aMCI/AD incidence and with global
                      cognitive and memory decline over time. The PRS association
                      was sex- and age-dependent, suggesting that these factors
                      should be considered in genetic modelling for AD.},
      keywords     = {Alzheimer’s disease (Other) / cognitive decline (Other) /
                      hippocampal atrophy (Other) / polygenic risk score (Other)},
      cin          = {Patient Studies (Bonn)},
      ddc          = {610},
      cid          = {I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39846584},
      doi          = {10.3390/geriatrics10010014},
      url          = {https://pub.dzne.de/record/276181},
}