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000276183 041__ $$aEnglish
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000276183 1001_ $$0P:(DE-2719)9002951$$aDörner, Marc$$b0$$eFirst author$$udzne
000276183 245__ $$aAssociations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms.
000276183 260__ $$a[London]$$bSpringer Nature$$c2025
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000276183 520__ $$aInferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker, further replication studies are required. The objective of this study was to investigate associations between IFSH and CSVD, and their potential repercussions, i.e., cognitive impairment and depression. We prospectively recruited 47 patients with CSVD and 29 cognitively normal controls (NC). IFSH were rated visually based on FLAIR MRI. Using different regression models, we explored the relationship between IFSH, group status (CSVD vs. NC), CSVD severity assessed with MRI, cognitive function, and symptoms of depression. Patients with CSVD were more likely to have higher IFSH scores compared to NC (OR 5.64, 95% CI 1.91-16.60), and greater CSVD severity on MRI predicted more severe IFSH (OR 1.47, 95% CI 1.14-1.88). Higher IFSH scores were associated with lower cognitive function (-0.96, 95% CI -1.81 to -0.10), and higher levels of depression (0.33, 95% CI 0.01-0.65). CSVD and IFSH may be tightly linked to each other, and the accumulation of waste products, indicated by IFSH, could have detrimental effects on cognitive function and symptoms of depression.
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000276183 650_7 $$2Other$$aCerebral amyloid angiopathy
000276183 650_7 $$2Other$$aCerebral small vessel disease
000276183 650_7 $$2Other$$aFluid-attenuated inversion recovery
000276183 650_7 $$2Other$$aGlymphatic system
000276183 650_7 $$2Other$$aHypertensive arteriopathy
000276183 650_7 $$2Other$$aInferior frontal sulcal hyperintensity
000276183 650_2 $$2MeSH$$aHumans
000276183 650_2 $$2MeSH$$aCerebral Small Vessel Diseases: diagnostic imaging
000276183 650_2 $$2MeSH$$aFemale
000276183 650_2 $$2MeSH$$aMale
000276183 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000276183 650_2 $$2MeSH$$aAged
000276183 650_2 $$2MeSH$$aDepression: diagnostic imaging
000276183 650_2 $$2MeSH$$aCognition: physiology
000276183 650_2 $$2MeSH$$aMiddle Aged
000276183 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000276183 650_2 $$2MeSH$$aProspective Studies
000276183 650_2 $$2MeSH$$aFrontal Lobe: diagnostic imaging
000276183 650_2 $$2MeSH$$aFrontal Lobe: pathology
000276183 650_2 $$2MeSH$$aBrain: diagnostic imaging
000276183 650_2 $$2MeSH$$aBrain: pathology
000276183 7001_ $$aPfister, Malte$$b1
000276183 7001_ $$aTyndall, Anthony$$b2
000276183 7001_ $$avon Känel, Roland$$b3
000276183 7001_ $$0P:(DE-2719)2810407$$aNeumann, Katja$$b4$$udzne
000276183 7001_ $$0P:(DE-2719)9000986$$aSchreiber, Frank$$b5$$udzne
000276183 7001_ $$0P:(DE-2719)9000797$$aArndt, Philipp$$b6$$udzne
000276183 7001_ $$aFuchs, Erelle$$b7
000276183 7001_ $$0P:(DE-2719)2813207$$aGarz, Cornelia$$b8$$udzne
000276183 7001_ $$0P:(DE-2719)2811614$$aGlanz, Wenzel$$b9$$udzne
000276183 7001_ $$0P:(DE-2719)9001011$$aButryn, Michaela$$b10$$udzne
000276183 7001_ $$aJohn, Anna-Charlotte$$b11
000276183 7001_ $$aHildebrand, Annkatrin$$b12
000276183 7001_ $$aEuler, Sebastian$$b13
000276183 7001_ $$aHofmann, Andreas B$$b14
000276183 7001_ $$aMachetanz, Lena$$b15
000276183 7001_ $$aKirchebner, Johannes$$b16
000276183 7001_ $$0P:(DE-2719)9002214$$aTacik, Pawel$$b17$$udzne
000276183 7001_ $$aGrimm, Alexander$$b18
000276183 7001_ $$aJansen, Robin$$b19
000276183 7001_ $$aPawlitzki, Marc$$b20
000276183 7001_ $$0P:(DE-2719)2813348$$aHenneicke, Solveig$$b21$$udzne
000276183 7001_ $$aPerosa, Valentina$$b22
000276183 7001_ $$aLabeit, Bendix$$b23
000276183 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b24$$udzne
000276183 7001_ $$aMeuth, Sven G$$b25
000276183 7001_ $$0P:(DE-2719)2000035$$aVielhaber, Stefan$$b26$$udzne
000276183 7001_ $$0P:(DE-2719)9002178$$aMattern, Hendrik$$b27$$udzne
000276183 7001_ $$0P:(DE-2719)9001989$$aBernal, Jose$$b28$$eLast author$$udzne
000276183 7001_ $$0P:(DE-2719)2812631$$aSchreiber, Stefanie$$b29$$eLast author$$udzne
000276183 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-025-87493-8$$gVol. 15, no. 1, p. 2999$$n1$$p2999$$tScientific reports$$v15$$x2045-2322$$y2025
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