TY  - JOUR
AU  - Dörner, Marc
AU  - Pfister, Malte
AU  - Tyndall, Anthony
AU  - von Känel, Roland
AU  - Neumann, Katja
AU  - Schreiber, Frank
AU  - Arndt, Philipp
AU  - Fuchs, Erelle
AU  - Garz, Cornelia
AU  - Glanz, Wenzel
AU  - Butryn, Michaela
AU  - John, Anna-Charlotte
AU  - Hildebrand, Annkatrin
AU  - Euler, Sebastian
AU  - Hofmann, Andreas B
AU  - Machetanz, Lena
AU  - Kirchebner, Johannes
AU  - Tacik, Pawel
AU  - Grimm, Alexander
AU  - Jansen, Robin
AU  - Pawlitzki, Marc
AU  - Henneicke, Solveig
AU  - Perosa, Valentina
AU  - Labeit, Bendix
AU  - Düzel, Emrah
AU  - Meuth, Sven G
AU  - Vielhaber, Stefan
AU  - Mattern, Hendrik
AU  - Bernal, Jose
AU  - Schreiber, Stefanie
TI  - Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms.
JO  - Scientific reports
VL  - 15
IS  - 1
SN  - 2045-2322
CY  - [London]
PB  - Springer Nature
M1  - DZNE-2025-00251
SP  - 2999
PY  - 2025
AB  - Inferior frontal sulcal hyperintensities (IFSH) observed on fluid-attenuated inversion recovery (FLAIR) MRI have been proposed as indicators of elevated cerebrospinal fluid waste accumulation in cerebral small vessel disease (CSVD). However, to validate IFSH as a reliable imaging biomarker, further replication studies are required. The objective of this study was to investigate associations between IFSH and CSVD, and their potential repercussions, i.e., cognitive impairment and depression. We prospectively recruited 47 patients with CSVD and 29 cognitively normal controls (NC). IFSH were rated visually based on FLAIR MRI. Using different regression models, we explored the relationship between IFSH, group status (CSVD vs. NC), CSVD severity assessed with MRI, cognitive function, and symptoms of depression. Patients with CSVD were more likely to have higher IFSH scores compared to NC (OR 5.64, 95
KW  - Humans
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Female
KW  - Male
KW  - Magnetic Resonance Imaging: methods
KW  - Aged
KW  - Depression: diagnostic imaging
KW  - Cognition: physiology
KW  - Middle Aged
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Prospective Studies
KW  - Frontal Lobe: diagnostic imaging
KW  - Frontal Lobe: pathology
KW  - Brain: diagnostic imaging
KW  - Brain: pathology
KW  - Cerebral amyloid angiopathy (Other)
KW  - Cerebral small vessel disease (Other)
KW  - Fluid-attenuated inversion recovery (Other)
KW  - Glymphatic system (Other)
KW  - Hypertensive arteriopathy (Other)
KW  - Inferior frontal sulcal hyperintensity (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39849098
DO  - DOI:10.1038/s41598-025-87493-8
UR  - https://pub.dzne.de/record/276183
ER  -