%0 Journal Article
%A Grazia, Alice
%A Dyrba, Martin
%A Pomara, Nunzio
%A Temp, Anna G
%A Grothe, Michel J
%A Teipel, Stefan J
%T Basal forebrain global functional connectivity is preserved in asymptomatic presenilin-1 E280A mutation carriers: Results from the Colombia cohort.
%J The journal of prevention of Alzheimer's disease
%V 12
%N 2
%@ 2274-5807
%C Cham
%I Springer International Publishing
%M DZNE-2025-00255
%P 100030
%D 2025
%X Imaging studies showed early atrophy of the cholinergic basal forebrain in prodromal sporadic Alzheimer's disease and reduced posterior basal forebrain functional connectivity in amyloid positive individuals with subjective cognitive decline. Similar investigations in familial cases of Alzheimer's disease are still lacking.To test whether presenilin-1 E280A mutation carriers have reduced basal forebrain functional connectivity and whether this is linked to amyloid pathology.This is a cross-sectional study that analyzes baseline functional imaging data.We obtained data from the Colombia cohort Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial.We analyzed data from 215 asymptomatic subjects carrying the presenilin-1 E280A mutation [64
%K Humans
%K Presenilin-1: genetics
%K Female
%K Colombia
%K Male
%K Cross-Sectional Studies
%K Adult
%K Magnetic Resonance Imaging
%K Mutation
%K Basal Forebrain: diagnostic imaging
%K Alzheimer Disease: genetics
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: physiopathology
%K Heterozygote
%K Cohort Studies
%K Middle Aged
%K Basal forebrain (Other)
%K Bayesian analysis (Other)
%K Colombia cohort (Other)
%K PSEN1 E280A (Other)
%K Resting-state fMRI (Other)
%K Presenilin-1 (NLM Chemicals)
%K PSEN1 protein, human (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39863323
%R 10.1016/j.tjpad.2024.100030
%U https://pub.dzne.de/record/276276