TY  - JOUR
AU  - Grazia, Alice
AU  - Dyrba, Martin
AU  - Pomara, Nunzio
AU  - Temp, Anna G
AU  - Grothe, Michel J
AU  - Teipel, Stefan J
TI  - Basal forebrain global functional connectivity is preserved in asymptomatic presenilin-1 E280A mutation carriers: Results from the Colombia cohort.
JO  - The journal of prevention of Alzheimer's disease
VL  - 12
IS  - 2
SN  - 2274-5807
CY  - Cham
PB  - Springer International Publishing
M1  - DZNE-2025-00255
SP  - 100030
PY  - 2025
AB  - Imaging studies showed early atrophy of the cholinergic basal forebrain in prodromal sporadic Alzheimer's disease and reduced posterior basal forebrain functional connectivity in amyloid positive individuals with subjective cognitive decline. Similar investigations in familial cases of Alzheimer's disease are still lacking.To test whether presenilin-1 E280A mutation carriers have reduced basal forebrain functional connectivity and whether this is linked to amyloid pathology.This is a cross-sectional study that analyzes baseline functional imaging data.We obtained data from the Colombia cohort Alzheimer's Prevention Initiative Autosomal-Dominant Alzheimer's Disease Trial.We analyzed data from 215 asymptomatic subjects carrying the presenilin-1 E280A mutation [64
KW  - Humans
KW  - Presenilin-1: genetics
KW  - Female
KW  - Colombia
KW  - Male
KW  - Cross-Sectional Studies
KW  - Adult
KW  - Magnetic Resonance Imaging
KW  - Mutation
KW  - Basal Forebrain: diagnostic imaging
KW  - Alzheimer Disease: genetics
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: physiopathology
KW  - Heterozygote
KW  - Cohort Studies
KW  - Middle Aged
KW  - Basal forebrain (Other)
KW  - Bayesian analysis (Other)
KW  - Colombia cohort (Other)
KW  - PSEN1 E280A (Other)
KW  - Resting-state fMRI (Other)
KW  - Presenilin-1 (NLM Chemicals)
KW  - PSEN1 protein, human (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39863323
DO  - DOI:10.1016/j.tjpad.2024.100030
UR  - https://pub.dzne.de/record/276276
ER  -