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000276318 1001_ $$00009-0000-9272-6535$$aKarneboge, Jonas$$b0
000276318 245__ $$aFacing the new diagnostic and treatment options of Alzheimer's disease: The necessity of informed consent.
000276318 260__ $$aHoboken, NJ$$bWiley$$c2025
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000276318 520__ $$aWith advances in biomarker-based detection of Alzheimer's disease (AD) and new treatment options with disease-modifying treatments (DMTs), we are heading toward a new conceptualization of diagnostics and therapy in the early stages of AD. Yet consensus guidelines on best clinical practices in predictive AD diagnostics are still developing. Currently, there is a knowledge gap regarding counseling and disclosure practices in early symptomatic disease stages, its implications for dementia risk estimation, and DMTs with associated risks and benefits. The crucial feature is the capacity of patients with (mild) cognitive impairment, eligible for DMTs, to consent. This perspective aims to (1) discuss the current challenges in assessing capacity to consent and (2) highlight the importance of a supported (informed) decision-making process. Measures to facilitate informed decision-making of patients constitute an ethical approach to enhancing the quality of care in this evolving therapeutic landscape. HIGHLIGHTS: This perspective: Explores biomarker-based early symptomatic AD detection and the implications for patient care. Emphasizes supported decision-making in DMTs for MCI and dementia patients. Discusses the need for standardized tools to assess the capacity to consent. Aligns diagnostic and treatment approaches with ethical care standards. Enhances patient autonomy in the evolving AD therapeutic landscape.
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000276318 650_7 $$2Other$$aanti‐amyloid therapy
000276318 650_7 $$2Other$$abiomarkers
000276318 650_7 $$2Other$$acapacity to consent
000276318 650_7 $$2Other$$acommunication
000276318 650_7 $$2Other$$adementia risk estimation
000276318 650_7 $$2Other$$aearly diagnosis
000276318 650_7 $$2Other$$ainformed consent
000276318 650_7 $$2Other$$asupported decision‐making
000276318 650_7 $$2NLM Chemicals$$aBiomarkers
000276318 650_2 $$2MeSH$$aHumans
000276318 650_2 $$2MeSH$$aAlzheimer Disease: diagnosis
000276318 650_2 $$2MeSH$$aAlzheimer Disease: therapy
000276318 650_2 $$2MeSH$$aAlzheimer Disease: drug therapy
000276318 650_2 $$2MeSH$$aInformed Consent
000276318 650_2 $$2MeSH$$aBiomarkers
000276318 650_2 $$2MeSH$$aCognitive Dysfunction: diagnosis
000276318 650_2 $$2MeSH$$aCognitive Dysfunction: therapy
000276318 650_2 $$2MeSH$$aDecision Making
000276318 650_2 $$2MeSH$$aMental Competency
000276318 7001_ $$00000-0003-3133-011X$$aHaberstroh, Julia$$b1
000276318 7001_ $$00000-0001-7311-0049$$aGeschke, Katharina$$b2
000276318 7001_ $$00000-0001-8112-0298$$aPerry, Julia$$b3
000276318 7001_ $$00009-0005-2409-6582$$aRadenbach, Katrin$$b4
000276318 7001_ $$0P:(DE-2719)2000032$$aJessen, Frank$$b5
000276318 7001_ $$00000-0001-5189-134X$$aRostamzadeh, Ayda$$b6
000276318 773__ $$0PERI:(DE-600)2201940-6$$a10.1002/alz.14204$$gVol. 21, no. 1, p. e14204$$n1$$pe14204$$tAlzheimer's and dementia$$v21$$x1552-5260$$y2025
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