000276319 001__ 276319
000276319 005__ 20260105141530.0
000276319 0247_ $$2doi$$a10.1111/jnc.16298
000276319 0247_ $$2pmid$$apmid:39871627
000276319 0247_ $$2pmc$$apmc:PMC11773302
000276319 0247_ $$2ISSN$$a0022-3042
000276319 0247_ $$2ISSN$$a1471-4159
000276319 0247_ $$2altmetric$$aaltmetric:173596308
000276319 037__ $$aDZNE-2025-00282
000276319 041__ $$aEnglish
000276319 082__ $$a610
000276319 1001_ $$aFitzgerald, Julia C$$b0
000276319 245__ $$aInteractions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra.
000276319 260__ $$aOxford$$bWiley-Blackwell$$c2025
000276319 3367_ $$2DRIVER$$aarticle
000276319 3367_ $$2DataCite$$aOutput Types/Journal article
000276319 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1738751813_26729
000276319 3367_ $$2BibTeX$$aARTICLE
000276319 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000276319 3367_ $$00$$2EndNote$$aJournal Article
000276319 520__ $$aParkinson's disease (PD) is a prevalent neurodegenerative disease caused by the death of dopaminergic neurons within the substantia nigra pars compacta (SNpc) region of the midbrain. Recent genomic and single cell sequencing data identified oligodendrocytes and oligodendrocyte precursor cells (OPCs) to confer genetic risk in PD, but their biological role is unknown. Although SNpc dopaminergic neurons are scarcely or thinly myelinated, there is a gap in the knowledge concerning the physiological interactions between dopaminergic neurons and oligodendroglia. We sought to investigate the distribution of OPCs with regard to the myelination state in the mouse substantia nigra (SN) by high-resolution imaging to provide a morphological assessment of OPC-dopaminergic neuron interactions and quantification of cell numbers across different age groups. OPCs are evenly distributed in the midbrain throughout the lifespan and they physically interact with both the soma and axons of dopaminergic neurons. The presence of OPCs and their interaction with dopaminergic neurons does not correlate with the distribution of myelin. Myelination is sparse in the SNpc, including dopaminergic fibers originating from the SNpc and projecting through the substantia nigra pars reticulata (SNpr). We report that OPCs and dopaminergic neurons exist in a 1:1 ratio in the SNpc, with OPCs accounting for 15%-16% of all cells in the region across all age groups. This description of OPC-dopaminergic neuron interaction in the midbrain provides a first look at their longitudinal distribution in mice, suggesting additional functions of OPCs beyond their differentiation into myelinating oligodendrocytes.
000276319 536__ $$0G:(DE-HGF)POF4-353$$a353 - Clinical and Health Care Research (POF4-353)$$cPOF4-353$$fPOF IV$$x0
000276319 588__ $$aDataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
000276319 650_7 $$2Other$$aOPCs
000276319 650_7 $$2Other$$aParkinson's disease
000276319 650_7 $$2Other$$aSNpc
000276319 650_7 $$2Other$$adopaminergic neurons
000276319 650_7 $$2Other$$amidbrain
000276319 650_7 $$2Other$$amouse brain
000276319 650_7 $$2Other$$aoligodendrocyte precursor cells
000276319 650_2 $$2MeSH$$aDopaminergic Neurons: physiology
000276319 650_2 $$2MeSH$$aAnimals
000276319 650_2 $$2MeSH$$aDopaminergic Neurons: metabolism
000276319 650_2 $$2MeSH$$aMice
000276319 650_2 $$2MeSH$$aSubstantia Nigra: cytology
000276319 650_2 $$2MeSH$$aOligodendrocyte Precursor Cells: metabolism
000276319 650_2 $$2MeSH$$aMice, Inbred C57BL
000276319 650_2 $$2MeSH$$aMale
000276319 650_2 $$2MeSH$$aFemale
000276319 650_2 $$2MeSH$$aMyelin Sheath: metabolism
000276319 650_2 $$2MeSH$$aOligodendroglia
000276319 650_2 $$2MeSH$$aCell Communication: physiology
000276319 650_2 $$2MeSH$$aSubstantia Nigra: metabolism
000276319 650_2 $$2MeSH$$aSubstantia Nigra: physiology
000276319 650_2 $$2MeSH$$aOligodendrocyte Precursor Cells: physiology
000276319 7001_ $$aSun, Ying$$b1
000276319 7001_ $$aReinecke, Frederek$$b2
000276319 7001_ $$aBauer, Elisabeth$$b3
000276319 7001_ $$aGaraschuk, Olga$$b4
000276319 7001_ $$0P:(DE-2719)2810803$$aKahle, Philipp J$$b5
000276319 7001_ $$00000-0002-6167-3263$$aPfeiffer, Friederike$$b6
000276319 773__ $$0PERI:(DE-600)2020528-4$$a10.1111/jnc.16298$$gVol. 169, no. 1, p. e16298$$n1$$pe16298$$tJournal of neurochemistry$$v169$$x0022-3042$$y2025
000276319 8564_ $$uhttps://pub.dzne.de/record/276319/files/DZNE-2025-00282%20SUP1.pdf
000276319 8564_ $$uhttps://pub.dzne.de/record/276319/files/DZNE-2025-00282.pdf$$yOpenAccess
000276319 8564_ $$uhttps://pub.dzne.de/record/276319/files/DZNE-2025-00282%20SUP1.pdf?subformat=pdfa$$xpdfa
000276319 8564_ $$uhttps://pub.dzne.de/record/276319/files/DZNE-2025-00282.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000276319 909CO $$ooai:pub.dzne.de:276319$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000276319 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810803$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000276319 9131_ $$0G:(DE-HGF)POF4-353$$1G:(DE-HGF)POF4-350$$2G:(DE-HGF)POF4-300$$3G:(DE-HGF)POF4$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lNeurodegenerative Diseases$$vClinical and Health Care Research$$x0
000276319 9141_ $$y2025
000276319 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0160$$2StatID$$aDBCoverage$$bEssential Science Indicators$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)1190$$2StatID$$aDBCoverage$$bBiological Abstracts$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ NEUROCHEM : 2022$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)3001$$2StatID$$aDEAL Wiley$$d2025-01-01$$wger
000276319 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0113$$2StatID$$aWoS$$bScience Citation Index Expanded$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000276319 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2025-01-01
000276319 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2025-01-01
000276319 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000276319 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2025-01-01$$wger
000276319 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2025-01-01
000276319 9201_ $$0I:(DE-2719)1210000$$kAG Gasser$$lParkinson Genetics$$x0
000276319 980__ $$ajournal
000276319 980__ $$aVDB
000276319 980__ $$aUNRESTRICTED
000276319 980__ $$aI:(DE-2719)1210000
000276319 9801_ $$aFullTexts