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@ARTICLE{Fitzgerald:276319,
      author       = {Fitzgerald, Julia C and Sun, Ying and Reinecke, Frederek
                      and Bauer, Elisabeth and Garaschuk, Olga and Kahle, Philipp
                      J and Pfeiffer, Friederike},
      title        = {{I}nteractions of {O}ligodendrocyte {P}recursor {C}ells and
                      {D}opaminergic {N}eurons in the {M}ouse {S}ubstantia
                      {N}igra.},
      journal      = {Journal of neurochemistry},
      volume       = {169},
      number       = {1},
      issn         = {0022-3042},
      address      = {Oxford},
      publisher    = {Wiley-Blackwell},
      reportid     = {DZNE-2025-00282},
      pages        = {e16298},
      year         = {2025},
      abstract     = {Parkinson's disease (PD) is a prevalent neurodegenerative
                      disease caused by the death of dopaminergic neurons within
                      the substantia nigra pars compacta (SNpc) region of the
                      midbrain. Recent genomic and single cell sequencing data
                      identified oligodendrocytes and oligodendrocyte precursor
                      cells (OPCs) to confer genetic risk in PD, but their
                      biological role is unknown. Although SNpc dopaminergic
                      neurons are scarcely or thinly myelinated, there is a gap in
                      the knowledge concerning the physiological interactions
                      between dopaminergic neurons and oligodendroglia. We sought
                      to investigate the distribution of OPCs with regard to the
                      myelination state in the mouse substantia nigra (SN) by
                      high-resolution imaging to provide a morphological
                      assessment of OPC-dopaminergic neuron interactions and
                      quantification of cell numbers across different age groups.
                      OPCs are evenly distributed in the midbrain throughout the
                      lifespan and they physically interact with both the soma and
                      axons of dopaminergic neurons. The presence of OPCs and
                      their interaction with dopaminergic neurons does not
                      correlate with the distribution of myelin. Myelination is
                      sparse in the SNpc, including dopaminergic fibers
                      originating from the SNpc and projecting through the
                      substantia nigra pars reticulata (SNpr). We report that OPCs
                      and dopaminergic neurons exist in a 1:1 ratio in the SNpc,
                      with OPCs accounting for $15\%-16\%$ of all cells in the
                      region across all age groups. This description of
                      OPC-dopaminergic neuron interaction in the midbrain provides
                      a first look at their longitudinal distribution in mice,
                      suggesting additional functions of OPCs beyond their
                      differentiation into myelinating oligodendrocytes.},
      keywords     = {Dopaminergic Neurons: physiology / Animals / Dopaminergic
                      Neurons: metabolism / Mice / Substantia Nigra: cytology /
                      Oligodendrocyte Precursor Cells: metabolism / Mice, Inbred
                      C57BL / Male / Female / Myelin Sheath: metabolism /
                      Oligodendroglia / Cell Communication: physiology /
                      Substantia Nigra: metabolism / Substantia Nigra: physiology
                      / Oligodendrocyte Precursor Cells: physiology / OPCs (Other)
                      / Parkinson's disease (Other) / SNpc (Other) / dopaminergic
                      neurons (Other) / midbrain (Other) / mouse brain (Other) /
                      oligodendrocyte precursor cells (Other)},
      cin          = {AG Gasser},
      ddc          = {610},
      cid          = {I:(DE-2719)1210000},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39871627},
      pmc          = {pmc:PMC11773302},
      doi          = {10.1111/jnc.16298},
      url          = {https://pub.dzne.de/record/276319},
}