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024 7 _ |a 10.1111/jnc.16298
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024 7 _ |a 1471-4159
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037 _ _ |a DZNE-2025-00282
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Fitzgerald, Julia C
|b 0
245 _ _ |a Interactions of Oligodendrocyte Precursor Cells and Dopaminergic Neurons in the Mouse Substantia Nigra.
260 _ _ |a Oxford
|c 2025
|b Wiley-Blackwell
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520 _ _ |a Parkinson's disease (PD) is a prevalent neurodegenerative disease caused by the death of dopaminergic neurons within the substantia nigra pars compacta (SNpc) region of the midbrain. Recent genomic and single cell sequencing data identified oligodendrocytes and oligodendrocyte precursor cells (OPCs) to confer genetic risk in PD, but their biological role is unknown. Although SNpc dopaminergic neurons are scarcely or thinly myelinated, there is a gap in the knowledge concerning the physiological interactions between dopaminergic neurons and oligodendroglia. We sought to investigate the distribution of OPCs with regard to the myelination state in the mouse substantia nigra (SN) by high-resolution imaging to provide a morphological assessment of OPC-dopaminergic neuron interactions and quantification of cell numbers across different age groups. OPCs are evenly distributed in the midbrain throughout the lifespan and they physically interact with both the soma and axons of dopaminergic neurons. The presence of OPCs and their interaction with dopaminergic neurons does not correlate with the distribution of myelin. Myelination is sparse in the SNpc, including dopaminergic fibers originating from the SNpc and projecting through the substantia nigra pars reticulata (SNpr). We report that OPCs and dopaminergic neurons exist in a 1:1 ratio in the SNpc, with OPCs accounting for 15%-16% of all cells in the region across all age groups. This description of OPC-dopaminergic neuron interaction in the midbrain provides a first look at their longitudinal distribution in mice, suggesting additional functions of OPCs beyond their differentiation into myelinating oligodendrocytes.
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650 _ 7 |a OPCs
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650 _ 7 |a Parkinson's disease
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650 _ 7 |a SNpc
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650 _ 7 |a dopaminergic neurons
|2 Other
650 _ 7 |a midbrain
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650 _ 7 |a mouse brain
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650 _ 7 |a oligodendrocyte precursor cells
|2 Other
650 _ 2 |a Dopaminergic Neurons: physiology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Dopaminergic Neurons: metabolism
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Substantia Nigra: cytology
|2 MeSH
650 _ 2 |a Oligodendrocyte Precursor Cells: metabolism
|2 MeSH
650 _ 2 |a Mice, Inbred C57BL
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Myelin Sheath: metabolism
|2 MeSH
650 _ 2 |a Oligodendroglia
|2 MeSH
650 _ 2 |a Cell Communication: physiology
|2 MeSH
650 _ 2 |a Substantia Nigra: metabolism
|2 MeSH
650 _ 2 |a Substantia Nigra: physiology
|2 MeSH
650 _ 2 |a Oligodendrocyte Precursor Cells: physiology
|2 MeSH
700 1 _ |a Sun, Ying
|b 1
700 1 _ |a Reinecke, Frederek
|b 2
700 1 _ |a Bauer, Elisabeth
|b 3
700 1 _ |a Garaschuk, Olga
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700 1 _ |a Kahle, Philipp J
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700 1 _ |a Pfeiffer, Friederike
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773 _ _ |a 10.1111/jnc.16298
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