%0 Journal Article
%A Krohn, Stephan
%A Müller-Jensen, Leonie
%A Kuchling, Joseph
%A Romanello, Amy
%A Wurdack, Katharina
%A Rekers, Sophia
%A Bartsch, Thorsten
%A Leypoldt, Frank
%A Paul, Friedemann
%A Ploner, Christoph J
%A Prüss, Harald
%A Finke, Carsten
%T Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.
%J Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
%V 12
%N 2
%@ 2332-7812
%C Philadelphia, Pa.
%I Wolters Kluwer
%M DZNE-2025-00284
%P e200360
%D 2025
%X Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.In this cross-sectional study, we combined clinical assessments, comprehensive neuropsychological testing, diffusion tensor MRI, probabilistic WM tractography, and computational network analysis in patients with LGI1-E referred to Charité-Universitätsmedizin Berlin. Healthy individuals were recruited as control participants and matched to patients for age and sex with logistic regression propensity scores.Twenty-five patients with LGI1-E (mean age = 63 ± 12 years, 76
%K Humans
%K Male
%K Female
%K Middle Aged
%K White Matter: diagnostic imaging
%K White Matter: pathology
%K Cognitive Dysfunction: etiology
%K Cognitive Dysfunction: physiopathology
%K Cognitive Dysfunction: diagnostic imaging
%K Aged
%K Cross-Sectional Studies
%K Immunotherapy: methods
%K Nerve Net: diagnostic imaging
%K Nerve Net: physiopathology
%K Nerve Net: pathology
%K Encephalitis: diagnostic imaging
%K Encephalitis: immunology
%K Intracellular Signaling Peptides and Proteins
%K Autoantibodies: blood
%K Diffusion Tensor Imaging
%K LGI1 protein, human (NLM Chemicals)
%K anti-leucine-rich glioma-inactivated 1 autoantibody (NLM Chemicals)
%K Intracellular Signaling Peptides and Proteins (NLM Chemicals)
%K Autoantibodies (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39879565
%R 10.1212/NXI.0000000000200360
%U https://pub.dzne.de/record/276321