TY  - JOUR
AU  - Krohn, Stephan
AU  - Müller-Jensen, Leonie
AU  - Kuchling, Joseph
AU  - Romanello, Amy
AU  - Wurdack, Katharina
AU  - Rekers, Sophia
AU  - Bartsch, Thorsten
AU  - Leypoldt, Frank
AU  - Paul, Friedemann
AU  - Ploner, Christoph J
AU  - Prüss, Harald
AU  - Finke, Carsten
TI  - Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.
JO  - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL  - 12
IS  - 2
SN  - 2332-7812
CY  - Philadelphia, Pa.
PB  - Wolters Kluwer
M1  - DZNE-2025-00284
SP  - e200360
PY  - 2025
AB  - Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.In this cross-sectional study, we combined clinical assessments, comprehensive neuropsychological testing, diffusion tensor MRI, probabilistic WM tractography, and computational network analysis in patients with LGI1-E referred to Charité-Universitätsmedizin Berlin. Healthy individuals were recruited as control participants and matched to patients for age and sex with logistic regression propensity scores.Twenty-five patients with LGI1-E (mean age = 63 ± 12 years, 76
KW  - Humans
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - White Matter: diagnostic imaging
KW  - White Matter: pathology
KW  - Cognitive Dysfunction: etiology
KW  - Cognitive Dysfunction: physiopathology
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Aged
KW  - Cross-Sectional Studies
KW  - Immunotherapy: methods
KW  - Nerve Net: diagnostic imaging
KW  - Nerve Net: physiopathology
KW  - Nerve Net: pathology
KW  - Encephalitis: diagnostic imaging
KW  - Encephalitis: immunology
KW  - Intracellular Signaling Peptides and Proteins
KW  - Autoantibodies: blood
KW  - Diffusion Tensor Imaging
KW  - LGI1 protein, human (NLM Chemicals)
KW  - anti-leucine-rich glioma-inactivated 1 autoantibody (NLM Chemicals)
KW  - Intracellular Signaling Peptides and Proteins (NLM Chemicals)
KW  - Autoantibodies (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39879565
DO  - DOI:10.1212/NXI.0000000000200360
UR  - https://pub.dzne.de/record/276321
ER  -