TY - JOUR
AU - Krohn, Stephan
AU - Müller-Jensen, Leonie
AU - Kuchling, Joseph
AU - Romanello, Amy
AU - Wurdack, Katharina
AU - Rekers, Sophia
AU - Bartsch, Thorsten
AU - Leypoldt, Frank
AU - Paul, Friedemann
AU - Ploner, Christoph J
AU - Prüss, Harald
AU - Finke, Carsten
TI - Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes.
JO - Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
VL - 12
IS - 2
SN - 2332-7812
CY - Philadelphia, Pa.
PB - Wolters Kluwer
M1 - DZNE-2025-00284
SP - e200360
PY - 2025
AB - Cognitive deficits represent a major long-term complication of anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E). Although severely affecting patient outcomes, the structural brain changes underlying these deficits remain poorly understood. In this study, we hypothesized a link between white matter (WM) networks and cognitive outcomes in LGI1-E.In this cross-sectional study, we combined clinical assessments, comprehensive neuropsychological testing, diffusion tensor MRI, probabilistic WM tractography, and computational network analysis in patients with LGI1-E referred to Charité-Universitätsmedizin Berlin. Healthy individuals were recruited as control participants and matched to patients for age and sex with logistic regression propensity scores.Twenty-five patients with LGI1-E (mean age = 63 ± 12 years, 76
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - White Matter: diagnostic imaging
KW - White Matter: pathology
KW - Cognitive Dysfunction: etiology
KW - Cognitive Dysfunction: physiopathology
KW - Cognitive Dysfunction: diagnostic imaging
KW - Aged
KW - Cross-Sectional Studies
KW - Immunotherapy: methods
KW - Nerve Net: diagnostic imaging
KW - Nerve Net: physiopathology
KW - Nerve Net: pathology
KW - Encephalitis: diagnostic imaging
KW - Encephalitis: immunology
KW - Intracellular Signaling Peptides and Proteins
KW - Autoantibodies: blood
KW - Diffusion Tensor Imaging
KW - LGI1 protein, human (NLM Chemicals)
KW - anti-leucine-rich glioma-inactivated 1 autoantibody (NLM Chemicals)
KW - Intracellular Signaling Peptides and Proteins (NLM Chemicals)
KW - Autoantibodies (NLM Chemicals)
LB - PUB:(DE-HGF)16
C6 - pmid:39879565
DO - DOI:10.1212/NXI.0000000000200360
UR - https://pub.dzne.de/record/276321
ER -