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000276323 1001_ $$00000-0003-3116-7789$$aBolsewig, Katharina$$b0
000276323 245__ $$aIncreased plasma DOPA decarboxylase levels in Lewy body disorders are driven by dopaminergic treatment.
000276323 260__ $$a[London]$$bSpringer Nature$$c2025
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000276323 520__ $$aDOPA Decarboxylase (DDC) has been proposed as a cerebrospinal fluid (CSF) biomarker with increased concentrations in Lewy body disorders (LBDs) and highest levels in patients receiving dopaminergic treatment. Here we evaluate plasma DDC, measured by proximity extension assay, and the effect of dopaminergic treatment in three independent LBD (with a focus on dementia with Lewy bodies (DLB) and Parkinson's disease (PD)) cohorts: an autopsy-confirmed cohort (n = 71), a large multicenter, cross-dementia cohort (n = 1498) and a longitudinal cohort with detailed treatment information (n = 66, median follow-up time[IQR] = 4[4, 4] years). Plasma DDC was not altered between different LBDs and other disease groups or controls in absence of treatment. DDC levels increased over time in PD, being significantly associated to higher dosages of dopaminergic treatment. This emphasizes the need to consider treatment effect when analyzing plasma DDC, and suggests that plasma DDC, in contrast to CSF DDC, is of limited use as a diagnostic biomarker for LBD, but could be valuable for treatment monitoring.
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000276323 650_7 $$0EC 4.1.1.-$$2NLM Chemicals$$aDopa Decarboxylase
000276323 650_7 $$2NLM Chemicals$$aBiomarkers
000276323 650_7 $$2NLM Chemicals$$aDopamine Agents
000276323 650_2 $$2MeSH$$aHumans
000276323 650_2 $$2MeSH$$aLewy Body Disease: drug therapy
000276323 650_2 $$2MeSH$$aLewy Body Disease: blood
000276323 650_2 $$2MeSH$$aLewy Body Disease: cerebrospinal fluid
000276323 650_2 $$2MeSH$$aDopa Decarboxylase: metabolism
000276323 650_2 $$2MeSH$$aMale
000276323 650_2 $$2MeSH$$aFemale
000276323 650_2 $$2MeSH$$aAged
000276323 650_2 $$2MeSH$$aParkinson Disease: drug therapy
000276323 650_2 $$2MeSH$$aParkinson Disease: blood
000276323 650_2 $$2MeSH$$aParkinson Disease: cerebrospinal fluid
000276323 650_2 $$2MeSH$$aBiomarkers: blood
000276323 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000276323 650_2 $$2MeSH$$aAged, 80 and over
000276323 650_2 $$2MeSH$$aMiddle Aged
000276323 650_2 $$2MeSH$$aDopamine Agents: therapeutic use
000276323 650_2 $$2MeSH$$aCohort Studies
000276323 650_2 $$2MeSH$$aLongitudinal Studies
000276323 7001_ $$aWillemse, Eline A J$$b1
000276323 7001_ $$aSánchez-Juan, Pascual$$b2
000276323 7001_ $$00000-0001-9320-6566$$aRábano, Alberto$$b3
000276323 7001_ $$00000-0002-9036-2595$$aMartínez, Minerva$$b4
000276323 7001_ $$00000-0003-2863-0293$$aDoecke, James D$$b5
000276323 7001_ $$00000-0003-0456-5650$$aBellomo, Giovanni$$b6
000276323 7001_ $$00000-0001-7420-6384$$aVermunt, Lisa$$b7
000276323 7001_ $$00000-0002-3819-3245$$aAlcolea, Daniel$$b8
000276323 7001_ $$0P:(DE-2719)9002026$$aHalbgebauer, Steffen$$b9
000276323 7001_ $$aIn 't Veld, Sjors$$b10
000276323 7001_ $$aMattsson-Carlgren, Niklas$$b11
000276323 7001_ $$00000-0002-5845-1854$$aVeverova, Katerina$$b12
000276323 7001_ $$aFowler, Christopher J$$b13
000276323 7001_ $$aBoonkamp, Lynn$$b14
000276323 7001_ $$aKoel-Simmelink, Marleen$$b15
000276323 7001_ $$aHussainali, Zulaiga$$b16
000276323 7001_ $$aRuiters, Daimy N$$b17
000276323 7001_ $$00000-0003-3967-8954$$aGaetani, Lorenzo$$b18
000276323 7001_ $$00009-0000-9500-7632$$aToja, Andrea$$b19
000276323 7001_ $$00000-0002-1340-638X$$aFortea, Juan$$b20
000276323 7001_ $$aPijnenburg, Yolande$$b21
000276323 7001_ $$aLemstra, Afina W$$b22
000276323 7001_ $$00000-0001-8766-6224$$avan der Flier, Wiesje M$$b23
000276323 7001_ $$aHort, Jakub$$b24
000276323 7001_ $$00000-0003-4273-4267$$aOtto, Markus$$b25
000276323 7001_ $$00000-0001-8467-7286$$aHansson, Oskar$$b26
000276323 7001_ $$00000-0001-5722-3967$$aParnetti, Lucilla$$b27
000276323 7001_ $$aMasters, Colin L$$b28
000276323 7001_ $$00000-0002-2568-5478$$aLleó, Alberto$$b29
000276323 7001_ $$00000-0002-4061-0837$$aTeunissen, Charlotte E$$b30
000276323 7001_ $$00000-0003-2808-3699$$aDel Campo Milán, Marta$$b31
000276323 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-025-56293-z$$gVol. 16, no. 1, p. 1139$$n1$$p1139$$tNature Communications$$v16$$x2041-1723$$y2025
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