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@ARTICLE{Bolsewig:276323,
      author       = {Bolsewig, Katharina and Willemse, Eline A J and
                      Sánchez-Juan, Pascual and Rábano, Alberto and Martínez,
                      Minerva and Doecke, James D and Bellomo, Giovanni and
                      Vermunt, Lisa and Alcolea, Daniel and Halbgebauer, Steffen
                      and In 't Veld, Sjors and Mattsson-Carlgren, Niklas and
                      Veverova, Katerina and Fowler, Christopher J and Boonkamp,
                      Lynn and Koel-Simmelink, Marleen and Hussainali, Zulaiga and
                      Ruiters, Daimy N and Gaetani, Lorenzo and Toja, Andrea and
                      Fortea, Juan and Pijnenburg, Yolande and Lemstra, Afina W
                      and van der Flier, Wiesje M and Hort, Jakub and Otto, Markus
                      and Hansson, Oskar and Parnetti, Lucilla and Masters, Colin
                      L and Lleó, Alberto and Teunissen, Charlotte E and Del
                      Campo Milán, Marta},
      title        = {{I}ncreased plasma {DOPA} decarboxylase levels in {L}ewy
                      body disorders are driven by dopaminergic treatment.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00286},
      pages        = {1139},
      year         = {2025},
      abstract     = {DOPA Decarboxylase (DDC) has been proposed as a
                      cerebrospinal fluid (CSF) biomarker with increased
                      concentrations in Lewy body disorders (LBDs) and highest
                      levels in patients receiving dopaminergic treatment. Here we
                      evaluate plasma DDC, measured by proximity extension assay,
                      and the effect of dopaminergic treatment in three
                      independent LBD (with a focus on dementia with Lewy bodies
                      (DLB) and Parkinson's disease (PD)) cohorts: an
                      autopsy-confirmed cohort (n = 71), a large multicenter,
                      cross-dementia cohort (n = 1498) and a longitudinal cohort
                      with detailed treatment information (n = 66, median
                      follow-up time[IQR] = 4[4, 4] years). Plasma DDC was not
                      altered between different LBDs and other disease groups or
                      controls in absence of treatment. DDC levels increased over
                      time in PD, being significantly associated to higher dosages
                      of dopaminergic treatment. This emphasizes the need to
                      consider treatment effect when analyzing plasma DDC, and
                      suggests that plasma DDC, in contrast to CSF DDC, is of
                      limited use as a diagnostic biomarker for LBD, but could be
                      valuable for treatment monitoring.},
      keywords     = {Humans / Lewy Body Disease: drug therapy / Lewy Body
                      Disease: blood / Lewy Body Disease: cerebrospinal fluid /
                      Dopa Decarboxylase: metabolism / Male / Female / Aged /
                      Parkinson Disease: drug therapy / Parkinson Disease: blood /
                      Parkinson Disease: cerebrospinal fluid / Biomarkers: blood /
                      Biomarkers: cerebrospinal fluid / Aged, 80 and over / Middle
                      Aged / Dopamine Agents: therapeutic use / Cohort Studies /
                      Longitudinal Studies / Dopa Decarboxylase (NLM Chemicals) /
                      Biomarkers (NLM Chemicals) / Dopamine Agents (NLM
                      Chemicals)},
      cin          = {Clinical Study Center (Ulm)},
      ddc          = {500},
      cid          = {I:(DE-2719)5000077},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39881147},
      doi          = {10.1038/s41467-025-56293-z},
      url          = {https://pub.dzne.de/record/276323},
}