%0 Journal Article
%A Lohner, Valerie
%A Perna, Laura
%A Schöttker, Ben
%A Perneczky, Robert
%A Brenner, Hermann
%A Mons, Ute
%T Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome.
%J Experimental gerontology
%V 200
%@ 0531-5565
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2025-00289
%P 112684
%D 2025
%X In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype.Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 
%K Humans
%K Biomarkers: blood
%K Female
%K Male
%K Aged
%K Middle Aged
%K Amyloid beta-Peptides: blood
%K Neurodegenerative Diseases: blood
%K Neurodegenerative Diseases: mortality
%K tau Proteins: blood
%K Glial Fibrillary Acidic Protein: blood
%K Stroke: blood
%K Stroke: mortality
%K Cardiovascular Diseases: mortality
%K Cardiovascular Diseases: blood
%K Proportional Hazards Models
%K Apolipoprotein E4: genetics
%K Neurofilament Proteins
%K Blood-based biomarkers of neurodegenerative diseases (Other)
%K Cerebrovascular events (Other)
%K Chronic coronary syndrome (Other)
%K Coronary heart disease (Other)
%K Epidemiology (Other)
%K Major cardiovascular events (Other)
%K Mortality (Other)
%K Biomarkers (NLM Chemicals)
%K Amyloid beta-Peptides (NLM Chemicals)
%K tau Proteins (NLM Chemicals)
%K Glial Fibrillary Acidic Protein (NLM Chemicals)
%K neurofilament protein L (NLM Chemicals)
%K GFAP protein, human (NLM Chemicals)
%K Apolipoprotein E4 (NLM Chemicals)
%K Neurofilament Proteins (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39824235
%R 10.1016/j.exger.2025.112684
%U https://pub.dzne.de/record/276341