TY  - JOUR
AU  - Lohner, Valerie
AU  - Perna, Laura
AU  - Schöttker, Ben
AU  - Perneczky, Robert
AU  - Brenner, Hermann
AU  - Mons, Ute
TI  - Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome.
JO  - Experimental gerontology
VL  - 200
SN  - 0531-5565
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2025-00289
SP  - 112684
PY  - 2025
AB  - In light of growing evidence highlighting interactions between cardiac and brain health, we investigated associations of biomarkers of neurodegenerative diseases with adverse outcomes (all-cause and cardiovascular mortality, major cardiovascular events, and stroke) in persons with chronic coronary syndrome (CCS).We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. These include biomarkers of neuronal (neurofilament light chain (NfL) (n = 379)) and glial neurodegeneration (glial fibrillary acidic protein (GFAP) (n = 379)), and Alzheimer's disease pathology (phosphorylated tau181 (n = 379), total tau (n = 377), and amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We applied Cox-proportional hazards models to evaluate associations of these biomarkers with adverse outcomes, adjusting for covariates and exploring interactions with apolipoprotein E (ApoE) ε4 genotype.Participants with higher NfL levels had increased rates of all-cause and cardiovascular mortality (Hazard ratio per increase by one standard deviation (95 
KW  - Humans
KW  - Biomarkers: blood
KW  - Female
KW  - Male
KW  - Aged
KW  - Middle Aged
KW  - Amyloid beta-Peptides: blood
KW  - Neurodegenerative Diseases: blood
KW  - Neurodegenerative Diseases: mortality
KW  - tau Proteins: blood
KW  - Glial Fibrillary Acidic Protein: blood
KW  - Stroke: blood
KW  - Stroke: mortality
KW  - Cardiovascular Diseases: mortality
KW  - Cardiovascular Diseases: blood
KW  - Proportional Hazards Models
KW  - Apolipoprotein E4: genetics
KW  - Neurofilament Proteins
KW  - Blood-based biomarkers of neurodegenerative diseases (Other)
KW  - Cerebrovascular events (Other)
KW  - Chronic coronary syndrome (Other)
KW  - Coronary heart disease (Other)
KW  - Epidemiology (Other)
KW  - Major cardiovascular events (Other)
KW  - Mortality (Other)
KW  - Biomarkers (NLM Chemicals)
KW  - Amyloid beta-Peptides (NLM Chemicals)
KW  - tau Proteins (NLM Chemicals)
KW  - Glial Fibrillary Acidic Protein (NLM Chemicals)
KW  - neurofilament protein L (NLM Chemicals)
KW  - GFAP protein, human (NLM Chemicals)
KW  - Apolipoprotein E4 (NLM Chemicals)
KW  - Neurofilament Proteins (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:39824235
DO  - DOI:10.1016/j.exger.2025.112684
UR  - https://pub.dzne.de/record/276341
ER  -