% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Lohner:276341,
      author       = {Lohner, Valerie and Perna, Laura and Schöttker, Ben and
                      Perneczky, Robert and Brenner, Hermann and Mons, Ute},
      title        = {{A}ssociations of blood-based biomarkers of
                      neurodegenerative diseases with mortality, cardio- and
                      cerebrovascular events in persons with chronic coronary
                      syndrome.},
      journal      = {Experimental gerontology},
      volume       = {200},
      issn         = {0531-5565},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-00289},
      pages        = {112684},
      year         = {2025},
      abstract     = {In light of growing evidence highlighting interactions
                      between cardiac and brain health, we investigated
                      associations of biomarkers of neurodegenerative diseases
                      with adverse outcomes (all-cause and cardiovascular
                      mortality, major cardiovascular events, and stroke) in
                      persons with chronic coronary syndrome (CCS).We used data
                      from a cohort of persons with CCS for whom major adverse
                      events were recorded over a follow-up of 20 years. We
                      measured biomarkers of neurodegenerative diseases in
                      baseline blood samples, using the Single-Molecule Array
                      Technology on a HD-1 Analyzer. These include biomarkers of
                      neuronal (neurofilament light chain (NfL) (n = 379)) and
                      glial neurodegeneration (glial fibrillary acidic protein
                      (GFAP) (n = 379)), and Alzheimer's disease pathology
                      (phosphorylated tau181 (n = 379), total tau (n = 377), and
                      amyloid β (Aβ40, Aβ42, Aβ42/Aβ40) (n = 377)). We
                      applied Cox-proportional hazards models to evaluate
                      associations of these biomarkers with adverse outcomes,
                      adjusting for covariates and exploring interactions with
                      apolipoprotein E (ApoE) ε4 genotype.Participants with
                      higher NfL levels had increased rates of all-cause and
                      cardiovascular mortality (Hazard ratio per increase by one
                      standard deviation (95 $\%$ confidence interval): all-cause
                      mortality: 1.36 (1.10-1.68); cardiovascular mortality: 1.42
                      (1.05-1.93)). The Aβ40/Aβ42-ratio was linked to incident
                      stroke (0.72 (0.52-1.00)). Associations of GFAP with
                      all-cause mortality and incident stroke were depending on
                      ApoE ε4 genotype. The other biomarkers were not
                      significantly associated with the studied outcomes.In
                      persons with CSS, NfL and the Aβ40/Aβ42-ratio were related
                      to mortality and incident stroke, respectively, whereas
                      associations of GFAP with adverse outcomes varied by ApoE
                      genotype. These biomarkers might play a role in linking
                      aging, cardiovascular and neurodegenerative diseases.},
      keywords     = {Humans / Biomarkers: blood / Female / Male / Aged / Middle
                      Aged / Amyloid beta-Peptides: blood / Neurodegenerative
                      Diseases: blood / Neurodegenerative Diseases: mortality /
                      tau Proteins: blood / Glial Fibrillary Acidic Protein: blood
                      / Stroke: blood / Stroke: mortality / Cardiovascular
                      Diseases: mortality / Cardiovascular Diseases: blood /
                      Proportional Hazards Models / Apolipoprotein E4: genetics /
                      Neurofilament Proteins / Blood-based biomarkers of
                      neurodegenerative diseases (Other) / Cerebrovascular events
                      (Other) / Chronic coronary syndrome (Other) / Coronary heart
                      disease (Other) / Epidemiology (Other) / Major
                      cardiovascular events (Other) / Mortality (Other) /
                      Biomarkers (NLM Chemicals) / Amyloid beta-Peptides (NLM
                      Chemicals) / tau Proteins (NLM Chemicals) / Glial Fibrillary
                      Acidic Protein (NLM Chemicals) / neurofilament protein L
                      (NLM Chemicals) / GFAP protein, human (NLM Chemicals) /
                      Apolipoprotein E4 (NLM Chemicals) / Neurofilament Proteins
                      (NLM Chemicals)},
      cin          = {AG Dichgans},
      ddc          = {610},
      cid          = {I:(DE-2719)5000022},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39824235},
      doi          = {10.1016/j.exger.2025.112684},
      url          = {https://pub.dzne.de/record/276341},
}