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000276344 1001_ $$0P:(DE-2719)9001302$$aBlömer, Simon$$b0$$eFirst author
000276344 245__ $$aProton-free induction decay MRSI at 7 T in the human brain using an egg-shaped modified rosette K-space trajectory.
000276344 260__ $$aNew York, NY [u.a.]$$bWiley-Liss$$c2025
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000276344 520__ $$aProton (1H)-MRSI via spatial-spectral encoding poses high demands on gradient hardware at ultra-high fields and high-resolutions. Rosette trajectories help alleviate these problems, but at reduced SNR-efficiency because of their k-space densities not matching any desired k-space filter. We propose modified rosette trajectories, which more closely match a Hamming filter, and thereby improve SNR performance while still staying within gradient hardware limitations and without prolonging scan time.Analytical and synthetic simulations were validated with phantom and in vivo measurements at 7 T. The rosette and modified rosette trajectories were measured in five healthy volunteers in 6 min in a 2D slice in the brain. An elliptical phase-encoding sequence was measured in one volunteer in 22 min, and a 3D sequence was measured in one volunteer within 19 min. The SNR per-unit-time, linewidth, Cramer-Rao lower bounds (CRLBs), lipid contamination, and data quality of the proposed modified rosette trajectory were compared to the rosette trajectory.Using the modified rosette trajectories, an improved k-space weighting function was achieved resulting in an SNR per-unit-time increase of up to 12% compared to rosette's and 23% compared to elliptical phase-encoding, dependent on the two additional trajectory parameters. Similar results were achieved for the theoretical SNR calculation based on k-space densities, as well as when using the pseudo-replica method for simulated, in vivo, and phantom data. The CRLBs of γ-aminobutyric acid and N-acetylaspartylglutamate improved non-significantly for the modified rosette trajectory, whereas the linewidths and lipid contamination remained similar.By optimizing the shape of the rosette trajectory, the modified rosette trajectories achieved higher SNR per-unit-time and enhanced data quality at the same scan time.
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000276344 650_7 $$2Other$$a7 T
000276344 650_7 $$2Other$$aSNR efficiency
000276344 650_7 $$2Other$$agradient hardware restrictions
000276344 650_7 $$2Other$$amagnetic resonance spectroscopic imaging
000276344 650_7 $$2Other$$amodified rosette trajectory
000276344 650_7 $$2Other$$anon‐Cartesian trajectory
000276344 650_7 $$2NLM Chemicals$$aProtons
000276344 650_2 $$2MeSH$$aHumans
000276344 650_2 $$2MeSH$$aPhantoms, Imaging
000276344 650_2 $$2MeSH$$aBrain: diagnostic imaging
000276344 650_2 $$2MeSH$$aAlgorithms
000276344 650_2 $$2MeSH$$aSignal-To-Noise Ratio
000276344 650_2 $$2MeSH$$aAdult
000276344 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000276344 650_2 $$2MeSH$$aProtons
000276344 650_2 $$2MeSH$$aComputer Simulation
000276344 650_2 $$2MeSH$$aMale
000276344 650_2 $$2MeSH$$aReproducibility of Results
000276344 650_2 $$2MeSH$$aFemale
000276344 650_2 $$2MeSH$$aImage Processing, Computer-Assisted: methods
000276344 650_2 $$2MeSH$$aHealthy Volunteers
000276344 7001_ $$aHingerl, Lukas$$b1
000276344 7001_ $$00000-0002-4727-2447$$aMarjańska, Małgorzata$$b2
000276344 7001_ $$aBogner, Wolfgang$$b3
000276344 7001_ $$00000-0002-6314-316X$$aMotyka, Stanislav$$b4
000276344 7001_ $$aHangel, Gilbert$$b5
000276344 7001_ $$aKlauser, Antoine$$b6
000276344 7001_ $$00000-0002-7412-0641$$aAndronesi, Ovidiu C$$b7
000276344 7001_ $$aStrasser, Bernhard$$b8
000276344 773__ $$0PERI:(DE-600)1493786-4$$a10.1002/mrm.30368$$gVol. 93, no. 4, p. 1443 - 1457$$n4$$p1443 - 1457$$tMagnetic resonance in medicine$$v93$$x1522-2594$$y2025
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