Home > Publications Database > Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older APOE4 Carriers. > print

001     276479
005     20250216000755.0
024 7 _ |a 10.1523/JNEUROSCI.1408-24.2024
|2 doi
024 7 _ |a pmid:39788739
|2 pmid
024 7 _ |a 0270-6474
|2 ISSN
024 7 _ |a 1529-2401
|2 ISSN
024 7 _ |a altmetric:172919076
|2 altmetric
037 _ _ |a DZNE-2025-00298
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Fischer, Larissa
|0 P:(DE-2719)9002356
|b 0
|e First author
|u dzne
245 _ _ |a Precuneus Activity during Retrieval Is Positively Associated with Amyloid Burden in Cognitively Normal Older APOE4 Carriers.
260 _ _ |a Washington, DC
|c 2025
|b Soc.
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1739438585_20872
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The precuneus is a site of early amyloid-beta (Aβ) accumulation. Previous cross-sectional studies reported increased precuneus fMRI activity in older adults with mild cognitive deficits or elevated Aβ. However, longitudinal studies in early Alzheimer's disease (AD) are lacking and the relationship to the Apolipoprotein-E (APOE) genotype is unclear. Investigating the PREVENT-AD dataset, we assessed how baseline and longitudinal precuneus activity during successful memory retrieval relates to future Aβ and tau burden and change in memory performance. We further studied the moderation by APOE4 genotype. We included 165 older adults (age, 62.8 ± 4.4 years; 113 female; 66 APOE4 carriers) who were cognitively normal at baseline with a family history of AD. All participants performed task-fMRI at baseline and underwent 18F-flortaucipir-PET and 18F-NAV4694-Aβ-PET on average 5 years later. We found that higher baseline activity and greater longitudinal increase in precuneus activity were associated with higher Aβ burden in APOE4 carriers but not noncarriers. We observed no effects of precuneus activity on tau burden. Finally, APOE4 noncarriers with low baseline precuneus activity exhibited better longitudinal performance in an independent memory test compared with (1) noncarriers with higher baseline activity and (2) APOE4 carriers. Our findings suggest that higher task-related precuneus activity during memory retrieval at baseline and over time are associated with greater Aβ burden in cognitively normal APOE4 carriers. Our results further indicate that the absence of 'hyperactivation' and the absence of the APOE4 allele is related with better future cognitive outcomes in cognitively normal older adults at risk for AD.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a APOE4
|2 Other
650 _ 7 |a amyloid
|2 Other
650 _ 7 |a episodic memory retrieval
|2 Other
650 _ 7 |a functional hyperactivity
|2 Other
650 _ 7 |a multimodal neuroimaging
|2 Other
650 _ 7 |a precuneus
|2 Other
650 _ 7 |a Apolipoprotein E4
|2 NLM Chemicals
650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 7 |a tau Proteins
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Apolipoprotein E4: genetics
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Parietal Lobe: metabolism
|2 MeSH
650 _ 2 |a Parietal Lobe: diagnostic imaging
|2 MeSH
650 _ 2 |a Parietal Lobe: physiopathology
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: metabolism
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging
|2 MeSH
650 _ 2 |a Heterozygote
|2 MeSH
650 _ 2 |a Positron-Emission Tomography
|2 MeSH
650 _ 2 |a Mental Recall: physiology
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Cognition: physiology
|2 MeSH
650 _ 2 |a tau Proteins: metabolism
|2 MeSH
650 _ 2 |a tau Proteins: genetics
|2 MeSH
700 1 _ |a Molloy, Eóin N.
|0 P:(DE-2719)9002180
|b 1
700 1 _ |a Pichet Binette, Alexa
|0 0000-0001-5218-3337
|b 2
700 1 _ |a Vockert, Niklas
|0 P:(DE-2719)9000804
|b 3
700 1 _ |a Marquardt, Jonas
|0 P:(DE-2719)9001692
|b 4
700 1 _ |a Pacha Pilar, Andrea
|0 P:(DE-2719)9002548
|b 5
|u dzne
700 1 _ |a Kreißl, Michael
|0 P:(DE-2719)2812799
|b 6
|u dzne
700 1 _ |a Remz, Jordana
|b 7
700 1 _ |a Tremblay-Mercier, Jennifer
|b 8
700 1 _ |a Poirier, Judes
|0 0000-0002-8018-4545
|b 9
700 1 _ |a Rajah, Maria Natasha
|b 10
700 1 _ |a Villeneuve, Sylvia
|0 0000-0003-2338-0467
|b 11
700 1 _ |a Group, PREVENT-AD Research
|b 12
|e Collaboration Author
700 1 _ |a Maass, Anne
|0 P:(DE-2719)2811815
|b 13
|e First author
773 _ _ |a 10.1523/JNEUROSCI.1408-24.2024
|g Vol. 45, no. 6, p. e1408242024 -
|0 PERI:(DE-600)1475274-8
|n 6
|p e1408242024
|t The journal of neuroscience
|v 45
|y 2025
|x 0270-6474
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/276479/files/DZNE-2025-00298.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/276479/files/DZNE-2025-00298.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:276479
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 0
|6 P:(DE-2719)9002356
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 1
|6 P:(DE-2719)9002180
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 3
|6 P:(DE-2719)9000804
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 4
|6 P:(DE-2719)9001692
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 5
|6 P:(DE-2719)9002548
910 1 _ |a External Institute
|0 I:(DE-HGF)0
|k Extern
|b 6
|6 P:(DE-2719)2812799
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 13
|6 P:(DE-2719)2811815
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
|d 2024-12-14
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b J NEUROSCI : 2022
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1030
|2 StatID
|b Current Contents - Life Sciences
|d 2024-12-14
915 _ _ |a WoS
|0 StatID:(DE-HGF)0113
|2 StatID
|b Science Citation Index Expanded
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-14
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
|d 2024-12-14
915 _ _ |a IF >= 5
|0 StatID:(DE-HGF)9905
|2 StatID
|b J NEUROSCI : 2022
|d 2024-12-14
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0160
|2 StatID
|b Essential Science Indicators
|d 2024-12-14
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-14
920 1 _ |0 I:(DE-2719)1311001
|k AG Maaß
|l Multimodal Neuroimaging
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1311001
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21