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000276481 1001_ $$aBeckröge, Tobias$$b0
000276481 245__ $$aImpaired primitive erythropoiesis and defective vascular development in Trim71-KO embryos.
000276481 260__ $$aHeidelberg$$bEMBO Press$$c2025
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000276481 520__ $$aThe transition of an embryo from gastrulation to organogenesis requires precisely coordinated changes in gene expression, but the underlying mechanisms remain unclear. The RNA-binding protein Trim71 is essential for development and serves as a potent regulator of post-transcriptional gene expression. Here, we show that global deficiency of Trim71 induces severe defects in mesoderm-derived cells at the onset of organogenesis. Murine Trim71-KO embryos displayed impaired primitive erythropoiesis, yolk sac vasculature, heart function, and circulation, explaining the embryonic lethality of these mice. Tie2 Cre Trim71 conditional knockout did not induce strong defects, showing that Trim71 expression in endothelial cells and their immediate progenitors is dispensable for embryonic survival. scRNA-seq of E7.5 global Trim71-KO embryos revealed that transcriptomic changes arise already at gastrulation, showing a strong up-regulation of the mesodermal pioneer transcription factor Eomes. We identify Eomes as a direct target of Trim71-mediated mRNA repression via the NHL domain, demonstrating a functional link between these important regulatory genes. Taken together, our data suggest that Trim71-dependent control of gene expression at gastrulation establishes a framework for proper development during organogenesis.
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000276481 650_7 $$2NLM Chemicals$$aT-Box Domain Proteins
000276481 650_7 $$2NLM Chemicals$$aRNA-Binding Proteins
000276481 650_2 $$2MeSH$$aAnimals
000276481 650_2 $$2MeSH$$aErythropoiesis: genetics
000276481 650_2 $$2MeSH$$aMice
000276481 650_2 $$2MeSH$$aMice, Knockout
000276481 650_2 $$2MeSH$$aGene Expression Regulation, Developmental: genetics
000276481 650_2 $$2MeSH$$aEmbryo, Mammalian: metabolism
000276481 650_2 $$2MeSH$$aOrganogenesis: genetics
000276481 650_2 $$2MeSH$$aYolk Sac: metabolism
000276481 650_2 $$2MeSH$$aYolk Sac: blood supply
000276481 650_2 $$2MeSH$$aYolk Sac: embryology
000276481 650_2 $$2MeSH$$aT-Box Domain Proteins: genetics
000276481 650_2 $$2MeSH$$aT-Box Domain Proteins: metabolism
000276481 650_2 $$2MeSH$$aGastrulation: genetics
000276481 650_2 $$2MeSH$$aEndothelial Cells: metabolism
000276481 650_2 $$2MeSH$$aFemale
000276481 650_2 $$2MeSH$$aRNA-Binding Proteins: metabolism
000276481 650_2 $$2MeSH$$aRNA-Binding Proteins: genetics
000276481 650_2 $$2MeSH$$aMesoderm: metabolism
000276481 650_2 $$2MeSH$$aMesoderm: embryology
000276481 7001_ $$aJux, Bettina$$b1
000276481 7001_ $$aSeifert, Hannah$$b2
000276481 7001_ $$aTheobald, Hannah$$b3
000276481 7001_ $$0P:(DE-2719)9000846$$aDe Domenico, Elena$$b4
000276481 7001_ $$0P:(DE-2719)9002116$$aPaulusch, Stefan$$b5$$udzne
000276481 7001_ $$0P:(DE-2719)2812219$$aBeyer, Marc$$b6$$udzne
000276481 7001_ $$0P:(DE-2719)2813805$$aSchlitzer, Andreas$$b7
000276481 7001_ $$aMass, Elvira$$b8
000276481 7001_ $$00000-0003-1325-9444$$aKolanus, Waldemar$$b9
000276481 773__ $$0PERI:(DE-600)2948687-7$$a10.26508/lsa.202402956$$gVol. 8, no. 4, p. e202402956 -$$n4$$pe202402956$$tLife science alliance$$v8$$x2575-1077$$y2025
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