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@ARTICLE{Liebscher:276485,
      author       = {Liebscher, Maxie and White, Silke and Hass, Simon and
                      Chocat, Anne and Mezenge, Florence and Landeau, Brigitte and
                      Delarue, Marion and Hébert, Oriane and Turpin, Anne-Laure
                      and Marchant, Natalie L. and Chételat, Gaël and
                      Klimecki-Lenz, Olga Maria and Poisnel, Géraldine and Wirth,
                      Miranka},
      title        = {{C}irculating {S}tress {H}ormones, {B}rain {H}ealth, and
                      {C}ognition in {H}ealthy {O}lder {A}dults:
                      {C}ross-{S}ectional {F}indings and {S}ex {D}ifferences in
                      {A}ge-{W}ell},
      journal      = {Biological psychiatry: global open science},
      volume       = {5},
      number       = {2},
      issn         = {2667-1743},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00302},
      pages        = {100431},
      year         = {2025},
      abstract     = {Background: Increased stress is a proposed risk factor for
                      Alzheimer’s disease (AD). We examined cross-sectional
                      associations between circulating stress biomarkers and
                      multimodal measures of brain health and cognition
                      susceptible to AD in older adults and sex-specific
                      subgroups.Methods: Baseline data from 132 cognitively
                      unimpaired participants without depression (age, mean ± SD
                      = 74.0 ± 4.0 years, women: n = 80) in the Age-Well trial
                      (NCT02977819) were included. Stress hormone levels were
                      measured in overnight fasting blood serum (cortisol,
                      dehydroepiandrosterone sulfate) and blood plasma
                      (epinephrine, norepinephrine) samples. AD-sensitive measures
                      of brain health, including glucose metabolism (n = 89),
                      cerebral perfusion, gray matter volume, amyloid deposition
                      in a priori regions of interest, and cognitive markers were
                      evaluated. Models were adjusted for age, sex, education,
                      trait anxiety, and depressive symptoms.Results: Higher
                      epinephrine levels were associated (false discovery
                      rate–corrected p < .05) with lower glucose metabolism in
                      the anterior cingulate cortex (β = −0.26, p = .008),
                      posterior cingulate cortex (β = −0.32, p = .006), and
                      precuneus (β = −0.27, p = .021) and lower perfusion in
                      the posterior cingulate cortex (β = −0.23, p = .013).
                      Interactions between stress hormones and sex showed (false
                      discovery rate–corrected p < .05) that in women only,
                      higher epinephrine was associated with larger anterior
                      cingulate cortex volume (interaction: β = 0.32, p = .016),
                      whereas in men only, higher cortisol was associated with
                      lower episodic memory performance (interaction: β = 0.98, p
                      = .012).Conclusions: The current study demonstrates the
                      involvement of circulating stress hormones, particularly
                      epinephrine and cortisol, in greater resilience or
                      vulnerability of brain health and cognitive indicators of
                      susceptibility to AD in older adults. The identification of
                      sex-specific patterns in these associations may inform the
                      development of more effective and tailored interventions.},
      cin          = {AG Wirth},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39990626},
      doi          = {10.1016/j.bpsgos.2024.100431},
      url          = {https://pub.dzne.de/record/276485},
}