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@ARTICLE{Liebscher:276485,
      author       = {Liebscher, Maxie and White, Silke and Hass, Simon and
                      Chocat, Anne and Mezenge, Florence and Landeau, Brigitte and
                      Delarue, Marion and Hébert, Oriane and Turpin, Anne-Laure
                      and Marchant, Natalie L. and Chételat, Gaël and
                      Klimecki-Lenz, Olga Maria and Poisnel, Géraldine and Wirth,
                      Miranka},
      title        = {{C}irculating {S}tress {H}ormones, {B}rain {H}ealth, and
                      {C}ognition in {H}ealthy {O}lder {A}dults:
                      {C}ross-{S}ectional {F}indings and {S}ex {D}ifferences in
                      {A}ge-{W}ell},
      journal      = {Biological psychiatry: global open science},
      volume       = {5},
      number       = {2},
      issn         = {2667-1743},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {DZNE-2025-00302},
      pages        = {100431},
      year         = {2025},
      abstract     = {Increased stress is a proposed risk factor for Alzheimer's
                      disease (AD). We examined cross-sectional associations
                      between circulating stress biomarkers and multimodal
                      measures of brain health and cognition susceptible to AD in
                      older adults and sex-specific subgroups.Baseline data from
                      132 cognitively unimpaired participants without depression
                      (age, mean ± SD = 74.0 ± 4.0 years, women: n = 80) in the
                      Age-Well trial (NCT02977819) were included. Stress hormone
                      levels were measured in overnight fasting blood serum
                      (cortisol, dehydroepiandrosterone sulfate) and blood plasma
                      (epinephrine, norepinephrine) samples. AD-sensitive measures
                      of brain health, including glucose metabolism (n = 89),
                      cerebral perfusion, gray matter volume, amyloid deposition
                      in a priori regions of interest, and cognitive markers were
                      evaluated. Models were adjusted for age, sex, education,
                      trait anxiety, and depressive symptoms.Higher epinephrine
                      levels were associated (false discovery rate-corrected p <
                      .05) with lower glucose metabolism in the anterior cingulate
                      cortex (β = -0.26, p = .008), posterior cingulate cortex
                      (β = -0.32, p = .006), and precuneus (β = -0.27, p = .021)
                      and lower perfusion in the posterior cingulate cortex (β =
                      -0.23, p = .013). Interactions between stress hormones and
                      sex showed (false discovery rate-corrected p < .05) that in
                      women only, higher epinephrine was associated with larger
                      anterior cingulate cortex volume (interaction: β = 0.32, p
                      = .016), whereas in men only, higher cortisol was associated
                      with lower episodic memory performance (interaction: β =
                      0.98, p = .012).The current study demonstrates the
                      involvement of circulating stress hormones, particularly
                      epinephrine and cortisol, in greater resilience or
                      vulnerability of brain health and cognitive indicators of
                      susceptibility to AD in older adults. The identification of
                      sex-specific patterns in these associations may inform the
                      development of more effective and tailored interventions.},
      cin          = {AG Wirth},
      ddc          = {610},
      cid          = {I:(DE-2719)1710011},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC11847304},
      pubmed       = {pmid:39990626},
      doi          = {10.1016/j.bpsgos.2024.100431},
      url          = {https://pub.dzne.de/record/276485},
}