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@ARTICLE{Boekholt:276486,
      author       = {Boekholt, Melanie and Nikelski, Angela and
                      Schumacher-Schönert, Fanny and Kracht, Friederike and
                      Vollmar, Horst Christian and Hoffmann, Wolfgang and Kreisel,
                      Stefan Henner and Thyrian, Jochen Rene},
      title        = {{S}upporting older people with cognitive impairment during
                      and after hospital stays with intersectoral care management
                      (intersec-{CM})-results of a randomised clinical trial.},
      journal      = {Age $\&$ ageing},
      volume       = {54},
      number       = {2},
      issn         = {0002-0729},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DZNE-2025-00303},
      pages        = {afaf011},
      year         = {2025},
      abstract     = {The transition from hospital to primary care is a risk
                      factor for negative health outcomes in people with cognitive
                      impairment.To test the effectiveness of intersectoral care
                      management during the transition from hospital to primary
                      care on repeated admission to hospital, functionality and
                      institutionalisation in people with cognitive
                      impairment.Longitudinal multisite randomised controlled
                      trial with two arms (care as usual and intersectoral care
                      management) and two follow-ups 3 and 12 months after
                      discharge.Three hospitals in two different primary care
                      regions in Germany.n = 401 people with cognitive impairment:
                      community-dwelling, age 70+. Randomised into control (n =
                      192) or intervention (n = 209).Primary outcomes for the
                      study after 3 months: admission to hospital, physical and
                      instrumental functionality. Primary outcome after 12 months:
                      institutionalisation, physical and instrumental
                      functionality. Secondary outcomes: health-related quality of
                      life, depressive symptoms, cognitive status and frailty.
                      Statistical analyses include descriptive analyses as well as
                      univariate and multivariate regression models for all
                      outcomes.There was no statistically significant effect of
                      the intervention on hospital admission and activities of
                      daily living after 3 months, as well as on
                      institutionalisation and activities of daily living after 12
                      months. There were significantly fewer participants in the
                      intervention group readmitted to the hospital 12 months
                      after discharge.Analyses show a significant effect on
                      health-related quality of life 3 months and 12 months after
                      discharge. Depressive symptoms were significantly less
                      likely in the intervention group 3 months after discharge.
                      No effects on cognition or frailty.Intersectoral care
                      management supports people with cognitive impairment during
                      discharge and transition. Even though we were not able to
                      show an impact of the intervention on the chosen primary
                      outcomes everyday functionality and institutionalisation,
                      the effects on health-related quality of life, hospital
                      admission rate and mental health are solid indicators for an
                      improved individual situation.ClinicalTrials.gov,
                      NCT03359408;
                      https://clinicaltrials.gov/ct2/show/NCT03359408.},
      keywords     = {Humans / Male / Female / Aged / Cognitive Dysfunction:
                      therapy / Cognitive Dysfunction: psychology / Quality of
                      Life / Aged, 80 and over / Germany / Activities of Daily
                      Living / Patient Discharge / Primary Health Care /
                      Institutionalization / Longitudinal Studies / Cognition /
                      Time Factors / Patient Readmission / Frailty: therapy /
                      Frailty: diagnosis / Frailty: psychology / Germany (Other) /
                      cognitive impairment (Other) / dementia care management
                      (Other) / hospital discharge (Other) / older people (Other)
                      / randomised controlled trial (Other)},
      cin          = {AG Thyrian / AG Hoffmann},
      ddc          = {610},
      cid          = {I:(DE-2719)1510800 / I:(DE-2719)1510600},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39912589},
      doi          = {10.1093/ageing/afaf011},
      url          = {https://pub.dzne.de/record/276486},
}