guest ::
| Home > Publications Database > High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study. > print |
| Home > Publications Database > High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study. > print |
| 001 | 276749 | ||
| 005 | 20250216000800.0 | ||
| 024 | 7 | _ | |a 10.1186/s12916-025-03919-0 |2 doi |
| 024 | 7 | _ | |a pmid:39920723 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC11806691 |2 pmc |
| 024 | 7 | _ | |a altmetric:173996823 |2 altmetric |
| 037 | _ | _ | |a DZNE-2025-00307 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Wicherski, Julia |0 P:(DE-2719)9000812 |b 0 |u dzne |
| 245 | _ | _ | |a High risk for life-threatening adverse events of fluoroquinolones in young adults: a large German population-based cohort study. |
| 260 | _ | _ | |a London |c 2025 |b BioMed Central |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1739454336_21758 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Fluoroquinolone antibiotics have a high potential for serious adverse drug reactions, but real-world evidence in European patient cohorts is lacking. Therefore, we aim to examine the association between fluoroquinolone exposure and potentially life-threatening adverse events stratified by age and gender in Germany.We conducted an administrative cohort study using the active comparator new user design with a risk window up to 365 days between January 2013 and December 2019. Population-based longitudinal data from one of the largest German statutory health insurances were used. Episodes of newly dispensed fluoroquinolones (ciprofloxacin, levofloxacin, ofloxacin, moxifloxacin, norfloxacin, and enoxacin) were compared to other antibiotics (amoxicillin, amoxicillin clavulanic acid, azithromycin, cefuroxime, cephalexin, clindamycin, sulfamethoxazole-trimethoprim, and doxycycline). Endpoints were defined by incident diagnoses of aortic aneurysm/dissection, cardiac arrhythmia, hepatotoxicity, and all-cause mortality. Adjusted hazard ratios were estimated from piece-wise exponential additive mixed models with smooth non-linear effects for person-time and age and adjusted for comorbidities, year and quarter at index.The cohorts comprised 15,139,840; 11,760,159; 11,027,175; and 15,305,757 antibiotic episodes. Patients during fluoroquinolone episodes were older (59 versus 51 years) and more often female (58% versus 54%). We counted 46,502; 446,727; 19,125; and 474,411 incident endpoints. Relative risk for all-cause mortality and hepatotoxicity was high for < 40-year- and 40-69-year-old females (aHR = 1.77, 95% CI 1.55-2.03 and aHR = 1.42, 95% CI 1.32-1.53), respectively. For aortic aneurysm/dissection a nominally increased relative risk for < 40-year-old females was found (aHR = 1.42, 95% CI 0.96-2.11), although 95% CI indicates that a small relative risk reduction is also supported by the data. Relative risk for cardiac arrhythmia was increased for men aged < 40 years (aHR = 1.14, 95% CI 1.08-1.20). High relative risks for each endpoint were also identified depending on choice of active comparator, and risks increased with higher defined daily doses and shorter follow-up.This study contributes real-world evidence to endpoint-specific differences of risks in patient subgroups which need to be considered to improve fluoroquinolone drug safety. |
| 536 | _ | _ | |a 354 - Disease Prevention and Healthy Aging (POF4-354) |0 G:(DE-HGF)POF4-354 |c POF4-354 |f POF IV |x 0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de |
| 650 | _ | 7 | |a Adverse drug reactions |2 Other |
| 650 | _ | 7 | |a Antibiotics |2 Other |
| 650 | _ | 7 | |a Cohort study |2 Other |
| 650 | _ | 7 | |a Fluoroquinolones |2 Other |
| 650 | _ | 7 | |a Real-world evidence |2 Other |
| 650 | _ | 7 | |a Fluoroquinolones |2 NLM Chemicals |
| 650 | _ | 7 | |a Anti-Bacterial Agents |2 NLM Chemicals |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Germany: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Fluoroquinolones: adverse effects |2 MeSH |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Anti-Bacterial Agents: adverse effects |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Young Adult |2 MeSH |
| 650 | _ | 2 | |a Arrhythmias, Cardiac: chemically induced |2 MeSH |
| 650 | _ | 2 | |a Arrhythmias, Cardiac: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Aortic Dissection: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Aortic Dissection: chemically induced |2 MeSH |
| 650 | _ | 2 | |a Chemical and Drug Induced Liver Injury: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Chemical and Drug Induced Liver Injury: etiology |2 MeSH |
| 650 | _ | 2 | |a Adolescent |2 MeSH |
| 650 | _ | 2 | |a Drug-Related Side Effects and Adverse Reactions: epidemiology |2 MeSH |
| 650 | _ | 2 | |a Age Factors |2 MeSH |
| 650 | _ | 2 | |a Risk Factors |2 MeSH |
| 700 | 1 | _ | |a Peltner, Jonas |0 P:(DE-2719)9002192 |b 1 |u dzne |
| 700 | 1 | _ | |a Becker, Cornelia |0 P:(DE-2719)9000482 |b 2 |u dzne |
| 700 | 1 | _ | |a Schüssel, Katrin |b 3 |
| 700 | 1 | _ | |a Brückner, Gabriela |b 4 |
| 700 | 1 | _ | |a Schlotmann, Andreas |b 5 |
| 700 | 1 | _ | |a Schröder, Helmut |b 6 |
| 700 | 1 | _ | |a Kern, Winfried V |b 7 |
| 700 | 1 | _ | |a Haenisch, Britta |0 P:(DE-2719)2810511 |b 8 |e Last author |u dzne |
| 773 | _ | _ | |a 10.1186/s12916-025-03919-0 |g Vol. 23, no. 1, p. 76 |0 PERI:(DE-600)2131669-7 |n 1 |p 76 |t BMC medicine |v 23 |y 2025 |x 1741-7015 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307%20SUP.docx |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307.pdf |
| 856 | 4 | _ | |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307%20SUP.doc |
| 856 | 4 | _ | |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307%20SUP.odt |
| 856 | 4 | _ | |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307%20SUP.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/276749/files/DZNE-2025-00307.pdf?subformat=pdfa |
| 909 | C | O | |o oai:pub.dzne.de:276749 |p openaire |p open_access |p VDB |p driver |p dnbdelivery |
| 910 | 1 | _ | |a External Institute |0 I:(DE-HGF)0 |k Extern |b 0 |6 P:(DE-2719)9000812 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 1 |6 P:(DE-2719)9002192 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)2810511 |
| 913 | 1 | _ | |a DE-HGF |b Gesundheit |l Neurodegenerative Diseases |1 G:(DE-HGF)POF4-350 |0 G:(DE-HGF)POF4-354 |3 G:(DE-HGF)POF4 |2 G:(DE-HGF)POF4-300 |4 G:(DE-HGF)POF |v Disease Prevention and Healthy Aging |x 0 |
| 914 | 1 | _ | |y 2025 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0200 |2 StatID |b SCOPUS |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0160 |2 StatID |b Essential Science Indicators |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1050 |2 StatID |b BIOSIS Previews |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1190 |2 StatID |b Biological Abstracts |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0600 |2 StatID |b Ebsco Academic Search |d 2024-12-05 |
| 915 | _ | _ | |a JCR |0 StatID:(DE-HGF)0100 |2 StatID |b BMC MED : 2022 |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0501 |2 StatID |b DOAJ Seal |d 2024-04-10T15:34:47Z |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0500 |2 StatID |b DOAJ |d 2024-04-10T15:34:47Z |
| 915 | _ | _ | |a WoS |0 StatID:(DE-HGF)0113 |2 StatID |b Science Citation Index Expanded |d 2024-12-05 |
| 915 | _ | _ | |a Fees |0 StatID:(DE-HGF)0700 |2 StatID |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0150 |2 StatID |b Web of Science Core Collection |d 2024-12-05 |
| 915 | _ | _ | |a Creative Commons Attribution CC BY 4.0 |0 LIC:(DE-HGF)CCBY4 |2 HGFVOC |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 915 | _ | _ | |a Peer Review |0 StatID:(DE-HGF)0030 |2 StatID |b ASC |d 2024-12-05 |
| 915 | _ | _ | |a Article Processing Charges |0 StatID:(DE-HGF)0561 |2 StatID |d 2024-12-05 |
| 915 | _ | _ | |a IF >= 5 |0 StatID:(DE-HGF)9905 |2 StatID |b BMC MED : 2022 |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0300 |2 StatID |b Medline |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)1110 |2 StatID |b Current Contents - Clinical Medicine |d 2024-12-05 |
| 915 | _ | _ | |a DBCoverage |0 StatID:(DE-HGF)0199 |2 StatID |b Clarivate Analytics Master Journal List |d 2024-12-05 |
| 920 | 1 | _ | |0 I:(DE-2719)1013010 |k AG Hänisch |l Pharmacoepidemiology |x 0 |
| 980 | _ | _ | |a journal |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | _ | _ | |a I:(DE-2719)1013010 |
| 980 | 1 | _ | |a FullTexts |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|