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@INPROCEEDINGS{Wagner:276751,
      author       = {Wagner, Felix and Karl, Mike O},
      title        = {{L}ive {I}maging {M}icroscopy of {H}uman {R}etina
                      {O}rganoids: {P}hotoreceptor {P}athology.},
      volume       = {1468},
      address      = {Cham},
      publisher    = {Springer Nature Switzerland},
      reportid     = {DZNE-2025-00309},
      isbn         = {978-3-031-76549-0 (print)},
      series       = {Advances in Experimental Medicine and Biology},
      pages        = {383 - 387},
      year         = {2025},
      comment      = {Retinal Degenerative Diseases XX / Bowes Rickman, Catherine
                      (Editor) ; Cham : Springer Nature Switzerland, 2025, Chapter
                      63 ; ISSN: 0065-2598=2214-8019 ; ISBN:
                      978-3-031-76549-0=978-3-031-76550-6 ;
                      doi:10.1007/978-3-031-76550-6},
      booktitle     = {Retinal Degenerative Diseases XX /
                       Bowes Rickman, Catherine (Editor) ;
                       Cham : Springer Nature Switzerland,
                       2025, Chapter 63 ; ISSN:
                       0065-2598=2214-8019 ; ISBN:
                       978-3-031-76549-0=978-3-031-76550-6 ;
                       doi:10.1007/978-3-031-76550-6},
      abstract     = {Neurodegenerative diseases involve many different
                      (sub)cellular pathologic processes like mitochondria damage,
                      which are still incompletely understood and present future
                      targets for therapy development. Live imaging microscopy of
                      dynamic pathologic changes at single cell resolution might
                      advance studies of pathomechanisms and biomarkers. Organoid
                      technologies may complement and facilitate animal and
                      patient studies: We recently reported a novel pathomechanism
                      of photoreceptor degeneration via cell extrusion, identified
                      and validated by live imaging in human retina organoids.
                      Here, we describe the related workflow for live imaging
                      organoid studies. As another use-case, we describe
                      mitochondrial alterations in photoreceptors acutely damaged
                      by the ionophore CCCP. Our data further support a
                      CCCP-induced experimental model for photoreceptor pathology,
                      which can be monitored by JC-1 live dye-assisted live
                      imaging. Thus, we demonstrate that live imaging advances
                      studies of early subcellular pathologic events in human
                      organoids. Such approaches might facilitate future
                      therapeutic target identification and development for early
                      intervention.},
      month         = {Jun},
      date          = {2011-06-08},
      organization  = {International Workshop on Ambient
                       Assisted Living, Torremolinos (Spain),
                       8 Jun 2011 - 10 Jun 2011},
      keywords     = {Organoids: pathology / Organoids: metabolism / Humans /
                      Photoreceptor Cells, Vertebrate: pathology / Photoreceptor
                      Cells, Vertebrate: metabolism / Retina: pathology / Retina:
                      metabolism / Mitochondria: metabolism / Mitochondria:
                      pathology / Retinal Degeneration: pathology / Retinal
                      Degeneration: metabolism / Human (Other) / Live imaging
                      (Other) / Mitochondria (Other) / Neurodegeneration (Other) /
                      Organoid (Other) / Retina (Other)},
      cin          = {AG Karl},
      ddc          = {570},
      cid          = {I:(DE-2719)1710004},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)8 / PUB:(DE-HGF)7},
      pubmed       = {pmid:39930226},
      doi          = {10.1007/978-3-031-76550-6_63},
      url          = {https://pub.dzne.de/record/276751},
}