% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Entenmann:276752,
      author       = {Entenmann, Christian J and von Bronewski, Emily J and
                      Waldmann, Lilly and Meyer, Lea and Kersting, Katharina and
                      Roolfs, Laurens T and Schleker, Lasse M and Nieminen-Kelhä,
                      Melina and Kremenetskaia, Irina and Heppner, Frank L and
                      Fehlings, Michael G and Vajkoczy, Peter and Hubertus,
                      Vanessa},
      title        = {{A}nalysis of the spatiotemporal dynamics of vascular
                      injury and regeneration following experimental {S}pinal
                      {C}ord {I}njury.},
      journal      = {Brain and spine},
      volume       = {5},
      issn         = {2772-5294},
      address      = {[Amsterdam]},
      publisher    = {Elsevier B.V.},
      reportid     = {DZNE-2025-00310},
      pages        = {104191},
      year         = {2025},
      abstract     = {The loss of vasculature in Spinal Cord Injury (SCI)
                      contributes to secondary injury, expanding the injury to
                      unharmed spinal cord (SC) regions. Understanding these
                      mechanisms is crucial for developing therapeutic
                      interventions.Comprehensive analysis of the temporospatial
                      dynamics of vascular injury and regeneration following
                      SCI.Adult C57BL/6J mice were subjected to clip-compression
                      SCI (Th 6/7, 5g, 60s, n = 20) or sham injury (laminectomy, n
                      = 4), and sacrificed at 1, 3, 7, 14, and 28 days (d)
                      post-injury following intracardial fluorescein
                      isothiocyanate (FITC)-Lectin perfusion. Histological
                      analysis (CD31, FITC-Lectin, Ki-67, IgG, TER-119) assessed
                      vascular changes, permeability, and proliferation within the
                      injury epicenter (region 0 (R0), ± 0,5 mm) and two adjacent
                      SC regions (R1: ± 1 mm, R2: ± 2.5 mm).Perfusion loss
                      (FITC-Lectin+/CD31+), was most severe in R0 and R1 at d3 (p
                      < 0.01). Significant vascular loss in R2 started at d3 (p =
                      0.043). Perfusion was restored at d28 in R0 and R1, and at
                      d7 in R2. Vessel density (CD31+) returned to baseline
                      quicker (R0: d3, R1 and R2: d14). Vascular proliferation
                      (CD31+/Ki-67+) manifested across all regions at d3 (p <
                      0.01), and most notably in R2 (p < 0.01). Vascular
                      permeability for IgG remained disrupted until d3 in R0 and
                      R1 and until d14 in R2.Vascular injury is most severe
                      initially and spreads to the surrounding SC regions. Gradual
                      vascular regeneration occurs early and up to a considerable
                      distance from the injury epicenter, highlighting the
                      potential of early therapeutic interventions targeted at
                      vascular repair and regeneration.},
      keywords     = {Angiogenesis (Other) / Blood spinal cord barrier (Other) /
                      Revascularization (Other) / Spinal cord injury (Other) /
                      Vascular injury (Other) / Vascular proliferation (Other)},
      cin          = {AG Heppner},
      ddc          = {610},
      cid          = {I:(DE-2719)1810007},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39935529},
      pmc          = {pmc:PMC11810697},
      doi          = {10.1016/j.bas.2025.104191},
      url          = {https://pub.dzne.de/record/276752},
}