Home > Publications Database > Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury. > print

001     276752
005     20250213170036.0
024 7 _ |a 10.1016/j.bas.2025.104191
|2 doi
024 7 _ |a pmid:39935529
|2 pmid
024 7 _ |a pmc:PMC11810697
|2 pmc
037 _ _ |a DZNE-2025-00310
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Entenmann, Christian J
|b 0
245 _ _ |a Analysis of the spatiotemporal dynamics of vascular injury and regeneration following experimental Spinal Cord Injury.
260 _ _ |a [Amsterdam]
|c 2025
|b Elsevier B.V.
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1739454160_23637
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The loss of vasculature in Spinal Cord Injury (SCI) contributes to secondary injury, expanding the injury to unharmed spinal cord (SC) regions. Understanding these mechanisms is crucial for developing therapeutic interventions.Comprehensive analysis of the temporospatial dynamics of vascular injury and regeneration following SCI.Adult C57BL/6J mice were subjected to clip-compression SCI (Th 6/7, 5g, 60s, n = 20) or sham injury (laminectomy, n = 4), and sacrificed at 1, 3, 7, 14, and 28 days (d) post-injury following intracardial fluorescein isothiocyanate (FITC)-Lectin perfusion. Histological analysis (CD31, FITC-Lectin, Ki-67, IgG, TER-119) assessed vascular changes, permeability, and proliferation within the injury epicenter (region 0 (R0), ± 0,5 mm) and two adjacent SC regions (R1: ± 1 mm, R2: ± 2.5 mm).Perfusion loss (FITC-Lectin+/CD31+), was most severe in R0 and R1 at d3 (p < 0.01). Significant vascular loss in R2 started at d3 (p = 0.043). Perfusion was restored at d28 in R0 and R1, and at d7 in R2. Vessel density (CD31+) returned to baseline quicker (R0: d3, R1 and R2: d14). Vascular proliferation (CD31+/Ki-67+) manifested across all regions at d3 (p < 0.01), and most notably in R2 (p < 0.01). Vascular permeability for IgG remained disrupted until d3 in R0 and R1 and until d14 in R2.Vascular injury is most severe initially and spreads to the surrounding SC regions. Gradual vascular regeneration occurs early and up to a considerable distance from the injury epicenter, highlighting the potential of early therapeutic interventions targeted at vascular repair and regeneration.
536 _ _ |a 353 - Clinical and Health Care Research (POF4-353)
|0 G:(DE-HGF)POF4-353
|c POF4-353
|f POF IV
|x 0
588 _ _ |a Dataset connected to CrossRef, PubMed, , Journals: pub.dzne.de
650 _ 7 |a Angiogenesis
|2 Other
650 _ 7 |a Blood spinal cord barrier
|2 Other
650 _ 7 |a Revascularization
|2 Other
650 _ 7 |a Spinal cord injury
|2 Other
650 _ 7 |a Vascular injury
|2 Other
650 _ 7 |a Vascular proliferation
|2 Other
700 1 _ |a von Bronewski, Emily J
|b 1
700 1 _ |a Waldmann, Lilly
|b 2
700 1 _ |a Meyer, Lea
|b 3
700 1 _ |a Kersting, Katharina
|b 4
700 1 _ |a Roolfs, Laurens T
|b 5
700 1 _ |a Schleker, Lasse M
|b 6
700 1 _ |a Nieminen-Kelhä, Melina
|b 7
700 1 _ |a Kremenetskaia, Irina
|b 8
700 1 _ |a Heppner, Frank L
|0 P:(DE-2719)2812386
|b 9
|u dzne
700 1 _ |a Fehlings, Michael G
|b 10
700 1 _ |a Vajkoczy, Peter
|b 11
700 1 _ |a Hubertus, Vanessa
|b 12
773 _ _ |a 10.1016/j.bas.2025.104191
|g Vol. 5, p. 104191 -
|0 PERI:(DE-600)3102718-0
|p 104191
|t Brain and spine
|v 5
|y 2025
|x 2772-5294
856 4 _ |y OpenAccess
|u https://pub.dzne.de/record/276752/files/DZNE-2025-00310.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://pub.dzne.de/record/276752/files/DZNE-2025-00310.pdf?subformat=pdfa
909 C O |o oai:pub.dzne.de:276752
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
|0 I:(DE-588)1065079516
|k DZNE
|b 9
|6 P:(DE-2719)2812386
913 1 _ |a DE-HGF
|b Gesundheit
|l Neurodegenerative Diseases
|1 G:(DE-HGF)POF4-350
|0 G:(DE-HGF)POF4-353
|3 G:(DE-HGF)POF4
|2 G:(DE-HGF)POF4-300
|4 G:(DE-HGF)POF
|v Clinical and Health Care Research
|x 0
914 1 _ |y 2025
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1190
|2 StatID
|b Biological Abstracts
|d 2024-12-27
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a WoS
|0 StatID:(DE-HGF)0112
|2 StatID
|b Emerging Sources Citation Index
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
|d 2022-10-27T06:47:36Z
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
|d 2022-10-27T06:47:36Z
915 _ _ |a Fees
|0 StatID:(DE-HGF)0700
|2 StatID
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
|d 2024-12-27
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Anonymous peer review
|d 2022-10-27T06:47:36Z
915 _ _ |a Article Processing Charges
|0 StatID:(DE-HGF)0561
|2 StatID
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
|d 2024-12-27
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
|d 2024-12-27
920 1 _ |0 I:(DE-2719)1810007
|k AG Heppner
|l Neuroimmunology
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-2719)1810007
980 1 _ |a FullTexts

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21