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000276778 041__ $$aEnglish
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000276778 1001_ $$00009-0009-7316-0471$$aSampatakakis, Stefanos N$$b0
000276778 245__ $$aGenetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population.
000276778 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2025
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000276778 520__ $$aIn the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study, comprising 512 cognitively normal individuals over 64 years of age, with a mean follow-up of 2.9 years. Cognitive function was evaluated through a neuropsychological test battery, while genetic predisposition was assessed based on two distinct Polygenic Risk Scores (PRS) for amyloid-beta 42 (Aβ42) and white matter hyperintensities (WMH). The association of each PRS with the cognitive decline rate was examined using generalized estimating equation models. In the whole sample, higher PRSs Aβ42 (β = -0.042) and WMH (β =-0.029) were associated with a higher rate of global cognitive decline per year, an association which remained significant in age, sex, and education subgroups. Moreover, higher PRSs Aβ42 and WMH were related to significant memory decline only in females, older, and highly educated participants. Thus, while the association of both PRSs with global cognitive decline over time was independent of age, sex, or education, the relationship of the specific PRSs with the memory decline rate appeared to vary depending on these factors.
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000276778 650_7 $$2Other$$aamyloid beta
000276778 650_7 $$2Other$$acognitive decline
000276778 650_7 $$2Other$$adementia
000276778 650_7 $$2Other$$apathophysiology
000276778 650_7 $$2Other$$apolygenic risk score
000276778 650_7 $$2Other$$awhite matter hyperintensities
000276778 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000276778 650_2 $$2MeSH$$aHumans
000276778 650_2 $$2MeSH$$aFemale
000276778 650_2 $$2MeSH$$aMale
000276778 650_2 $$2MeSH$$aAged
000276778 650_2 $$2MeSH$$aCognitive Dysfunction: genetics
000276778 650_2 $$2MeSH$$aDementia: genetics
000276778 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000276778 650_2 $$2MeSH$$aGenetic Predisposition to Disease
000276778 650_2 $$2MeSH$$aAged, 80 and over
000276778 650_2 $$2MeSH$$aLongitudinal Studies
000276778 650_2 $$2MeSH$$aNeuropsychological Tests
000276778 650_2 $$2MeSH$$aWhite Matter: pathology
000276778 650_2 $$2MeSH$$aWhite Matter: diagnostic imaging
000276778 650_2 $$2MeSH$$aMultifactorial Inheritance
000276778 7001_ $$aMourtzi, Niki$$b1
000276778 7001_ $$aHatzimanolis, Alex$$b2
000276778 7001_ $$00000-0002-8980-8377$$aKoutsis, Georgios$$b3
000276778 7001_ $$00000-0001-6578-393X$$aCharisis, Sokratis$$b4
000276778 7001_ $$aGkelmpesi, Iliana$$b5
000276778 7001_ $$aMamalaki, Eirini$$b6
000276778 7001_ $$aNtanasi, Eva$$b7
000276778 7001_ $$0P:(DE-2719)2812825$$aRamirez, Alfredo$$b8
000276778 7001_ $$00000-0003-2171-7337$$aYannakoulia, Mary$$b9
000276778 7001_ $$00000-0001-8790-1220$$aKosmidis, Mary H$$b10
000276778 7001_ $$00000-0003-2957-641X$$aDardiotis, Efthimios$$b11
000276778 7001_ $$aHadjigeorgiou, Georgios$$b12
000276778 7001_ $$aSakka, Paraskevi$$b13
000276778 7001_ $$aScarmeas, Nikolaos$$b14
000276778 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms26030910$$gVol. 26, no. 3, p. 910 -$$n3$$p910$$tInternational journal of molecular sciences$$v26$$x1422-0067$$y2025
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