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@ARTICLE{Sampatakakis:276778,
      author       = {Sampatakakis, Stefanos N and Mourtzi, Niki and
                      Hatzimanolis, Alex and Koutsis, Georgios and Charisis,
                      Sokratis and Gkelmpesi, Iliana and Mamalaki, Eirini and
                      Ntanasi, Eva and Ramirez, Alfredo and Yannakoulia, Mary and
                      Kosmidis, Mary H and Dardiotis, Efthimios and Hadjigeorgiou,
                      Georgios and Sakka, Paraskevi and Scarmeas, Nikolaos},
      title        = {{G}enetic {P}rοpensity for {D}ifferent {A}spects of
                      {D}ementia {P}athology and {C}ognitive {D}ecline in a
                      {C}ommunity {E}lderly {P}opulation.},
      journal      = {International journal of molecular sciences},
      volume       = {26},
      number       = {3},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {DZNE-2025-00317},
      pages        = {910},
      year         = {2025},
      abstract     = {In the present study, we investigated the association of
                      genetic predisposition with specific dimensions of dementia
                      pathophysiology for global and domain-specific cognitive
                      decline in older adults. The sample was drawn from the
                      Hellenic Longitudinal Investigation of Aging and Diet
                      (HELIAD) study, comprising 512 cognitively normal
                      individuals over 64 years of age, with a mean follow-up of
                      2.9 years. Cognitive function was evaluated through a
                      neuropsychological test battery, while genetic
                      predisposition was assessed based on two distinct Polygenic
                      Risk Scores (PRS) for amyloid-beta 42 (Aβ42) and white
                      matter hyperintensities (WMH). The association of each PRS
                      with the cognitive decline rate was examined using
                      generalized estimating equation models. In the whole sample,
                      higher PRSs Aβ42 (β = -0.042) and WMH (β =-0.029) were
                      associated with a higher rate of global cognitive decline
                      per year, an association which remained significant in age,
                      sex, and education subgroups. Moreover, higher PRSs Aβ42
                      and WMH were related to significant memory decline only in
                      females, older, and highly educated participants. Thus,
                      while the association of both PRSs with global cognitive
                      decline over time was independent of age, sex, or education,
                      the relationship of the specific PRSs with the memory
                      decline rate appeared to vary depending on these factors.},
      keywords     = {Humans / Female / Male / Aged / Cognitive Dysfunction:
                      genetics / Dementia: genetics / Amyloid beta-Peptides:
                      metabolism / Genetic Predisposition to Disease / Aged, 80
                      and over / Longitudinal Studies / Neuropsychological Tests /
                      White Matter: pathology / White Matter: diagnostic imaging /
                      Multifactorial Inheritance / amyloid beta (Other) /
                      cognitive decline (Other) / dementia (Other) /
                      pathophysiology (Other) / polygenic risk score (Other) /
                      white matter hyperintensities (Other) / Amyloid
                      beta-Peptides (NLM Chemicals)},
      cin          = {Patient Studies (Bonn)},
      ddc          = {540},
      cid          = {I:(DE-2719)1011101},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39940679},
      doi          = {10.3390/ijms26030910},
      url          = {https://pub.dzne.de/record/276778},
}