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001     276778
005     20250323000830.0
024 7 _ |a 10.3390/ijms26030910
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024 7 _ |a pmid:39940679
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024 7 _ |a 1422-0067
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024 7 _ |a 1661-6596
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024 7 _ |a altmetric:174179825
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037 _ _ |a DZNE-2025-00317
041 _ _ |a English
082 _ _ |a 540
100 1 _ |a Sampatakakis, Stefanos N
|0 0009-0009-7316-0471
|b 0
245 _ _ |a Genetic Prοpensity for Different Aspects of Dementia Pathology and Cognitive Decline in a Community Elderly Population.
260 _ _ |a Basel
|c 2025
|b Molecular Diversity Preservation International
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520 _ _ |a In the present study, we investigated the association of genetic predisposition with specific dimensions of dementia pathophysiology for global and domain-specific cognitive decline in older adults. The sample was drawn from the Hellenic Longitudinal Investigation of Aging and Diet (HELIAD) study, comprising 512 cognitively normal individuals over 64 years of age, with a mean follow-up of 2.9 years. Cognitive function was evaluated through a neuropsychological test battery, while genetic predisposition was assessed based on two distinct Polygenic Risk Scores (PRS) for amyloid-beta 42 (Aβ42) and white matter hyperintensities (WMH). The association of each PRS with the cognitive decline rate was examined using generalized estimating equation models. In the whole sample, higher PRSs Aβ42 (β = -0.042) and WMH (β =-0.029) were associated with a higher rate of global cognitive decline per year, an association which remained significant in age, sex, and education subgroups. Moreover, higher PRSs Aβ42 and WMH were related to significant memory decline only in females, older, and highly educated participants. Thus, while the association of both PRSs with global cognitive decline over time was independent of age, sex, or education, the relationship of the specific PRSs with the memory decline rate appeared to vary depending on these factors.
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650 _ 7 |a amyloid beta
|2 Other
650 _ 7 |a cognitive decline
|2 Other
650 _ 7 |a dementia
|2 Other
650 _ 7 |a pathophysiology
|2 Other
650 _ 7 |a polygenic risk score
|2 Other
650 _ 7 |a white matter hyperintensities
|2 Other
650 _ 7 |a Amyloid beta-Peptides
|2 NLM Chemicals
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: genetics
|2 MeSH
650 _ 2 |a Dementia: genetics
|2 MeSH
650 _ 2 |a Amyloid beta-Peptides: metabolism
|2 MeSH
650 _ 2 |a Genetic Predisposition to Disease
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Longitudinal Studies
|2 MeSH
650 _ 2 |a Neuropsychological Tests
|2 MeSH
650 _ 2 |a White Matter: pathology
|2 MeSH
650 _ 2 |a White Matter: diagnostic imaging
|2 MeSH
650 _ 2 |a Multifactorial Inheritance
|2 MeSH
700 1 _ |a Mourtzi, Niki
|b 1
700 1 _ |a Hatzimanolis, Alex
|b 2
700 1 _ |a Koutsis, Georgios
|0 0000-0002-8980-8377
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700 1 _ |a Charisis, Sokratis
|0 0000-0001-6578-393X
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700 1 _ |a Gkelmpesi, Iliana
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700 1 _ |a Mamalaki, Eirini
|b 6
700 1 _ |a Ntanasi, Eva
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700 1 _ |a Ramirez, Alfredo
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700 1 _ |a Yannakoulia, Mary
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700 1 _ |a Kosmidis, Mary H
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700 1 _ |a Dardiotis, Efthimios
|0 0000-0003-2957-641X
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700 1 _ |a Hadjigeorgiou, Georgios
|b 12
700 1 _ |a Sakka, Paraskevi
|b 13
700 1 _ |a Scarmeas, Nikolaos
|b 14
773 _ _ |a 10.3390/ijms26030910
|g Vol. 26, no. 3, p. 910 -
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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