%0 Journal Article
%A Stringer, Michael S
%A Blair, Gordon W
%A Kopczak, Anna
%A Kerkhofs, Danielle
%A Thrippleton, Michael J
%A Chappell, Francesca M
%A Maniega, Susana Muñoz
%A Brown, Rosalind
%A Shuler, Kirsten
%A Hamilton, Iona
%A Garcia, Daniela Jaime
%A Doubal, Fergus N
%A Clancy, Una
%A Sakka, Eleni
%A Poliakova, Tetiana
%A Janssen, Esther
%A Duering, Marco
%A Ingrisch, Michael
%A Staals, Julie
%A Backes, Walter H
%A van Oostenbrugge, Robert
%A Biessels, Geert Jan
%A Dichgans, Martin
%A Wardlaw, Joanna M
%T Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease.
%J Annals of neurology
%V 97
%N 3
%@ 0364-5134
%C Hoboken, NJ
%I Wiley-Blackwell
%M DZNE-2025-00319
%P 483 - 498
%D 2025
%X Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood-brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies assessed all 3 functions concurrently. We assessed 3 key vascular functions in sporadic and genetic SVD to determine associations with SVD severity, subtype, and interrelations.In this prospective, cross-sectional, multicenter INVESTIGATE-SVDs study, we acquired brain magnetic resonance imaging in patients with sporadic SVD/cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), including structural, quantitative microstructural, permeability surface area product, blood plasma volume fraction, vascular pulsatility, and CVR (in response to CO2) scans. We determined vascular function and white matter hyperintensity (WMH) associations, using covariate-adjusted linear regression; normal-appearing white matter and WMH differences, interrelationships between vascular functions, using linear mixed models; and major sources of variance using principal component analyses.We recruited 77 patients (45 sporadic/32 CADASIL) at 3 sites. In adjusted analyses, patients with worse WMH had lower CVR (B = -1.78, 95
%K Humans
%K Female
%K Male
%K Middle Aged
%K Cerebral Small Vessel Diseases: genetics
%K Cerebral Small Vessel Diseases: diagnostic imaging
%K Cerebral Small Vessel Diseases: physiopathology
%K Cross-Sectional Studies
%K Aged
%K Magnetic Resonance Imaging
%K Prospective Studies
%K CADASIL: genetics
%K CADASIL: physiopathology
%K CADASIL: diagnostic imaging
%K Cerebrovascular Circulation: physiology
%K White Matter: diagnostic imaging
%K White Matter: pathology
%K Adult
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39552538
%2 pmc:PMC11831873
%R 10.1002/ana.27136
%U https://pub.dzne.de/record/276782