TY  - JOUR
AU  - Stringer, Michael S
AU  - Blair, Gordon W
AU  - Kopczak, Anna
AU  - Kerkhofs, Danielle
AU  - Thrippleton, Michael J
AU  - Chappell, Francesca M
AU  - Maniega, Susana Muñoz
AU  - Brown, Rosalind
AU  - Shuler, Kirsten
AU  - Hamilton, Iona
AU  - Garcia, Daniela Jaime
AU  - Doubal, Fergus N
AU  - Clancy, Una
AU  - Sakka, Eleni
AU  - Poliakova, Tetiana
AU  - Janssen, Esther
AU  - Duering, Marco
AU  - Ingrisch, Michael
AU  - Staals, Julie
AU  - Backes, Walter H
AU  - van Oostenbrugge, Robert
AU  - Biessels, Geert Jan
AU  - Dichgans, Martin
AU  - Wardlaw, Joanna M
TI  - Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease.
JO  - Annals of neurology
VL  - 97
IS  - 3
SN  - 0364-5134
CY  - Hoboken, NJ
PB  - Wiley-Blackwell
M1  - DZNE-2025-00319
SP  - 483 - 498
PY  - 2025
AB  - Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood-brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactivity (CVR). No studies assessed all 3 functions concurrently. We assessed 3 key vascular functions in sporadic and genetic SVD to determine associations with SVD severity, subtype, and interrelations.In this prospective, cross-sectional, multicenter INVESTIGATE-SVDs study, we acquired brain magnetic resonance imaging in patients with sporadic SVD/cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), including structural, quantitative microstructural, permeability surface area product, blood plasma volume fraction, vascular pulsatility, and CVR (in response to CO2) scans. We determined vascular function and white matter hyperintensity (WMH) associations, using covariate-adjusted linear regression; normal-appearing white matter and WMH differences, interrelationships between vascular functions, using linear mixed models; and major sources of variance using principal component analyses.We recruited 77 patients (45 sporadic/32 CADASIL) at 3 sites. In adjusted analyses, patients with worse WMH had lower CVR (B = -1.78, 95
KW  - Humans
KW  - Female
KW  - Male
KW  - Middle Aged
KW  - Cerebral Small Vessel Diseases: genetics
KW  - Cerebral Small Vessel Diseases: diagnostic imaging
KW  - Cerebral Small Vessel Diseases: physiopathology
KW  - Cross-Sectional Studies
KW  - Aged
KW  - Magnetic Resonance Imaging
KW  - Prospective Studies
KW  - CADASIL: genetics
KW  - CADASIL: physiopathology
KW  - CADASIL: diagnostic imaging
KW  - Cerebrovascular Circulation: physiology
KW  - White Matter: diagnostic imaging
KW  - White Matter: pathology
KW  - Adult
LB  - PUB:(DE-HGF)16
C6  - pmid:39552538
C2  - pmc:PMC11831873
DO  - DOI:10.1002/ana.27136
UR  - https://pub.dzne.de/record/276782
ER  -