%0 Journal Article
%A Krauss, Jonas
%A Upadhyay, Neeraj
%A Purrer, Veronika
%A Borger, Valeri
%A Daamen, Marcel
%A Schmitt, Angelika
%A Schmeel, Carsten
%A Radbruch, Alexander
%A Wüllner, Ullrich
%A Boecker, Henning
%T Beyond the cerebello-thalamo-cortical tract: Remote structural changes after VIM-MRgFUS in essential tremor.
%J Parkinsonism & related disorders
%V 132
%@ 1353-8020
%C Amsterdam [u.a.]
%I Elsevier Science
%M DZNE-2025-00338
%P 107318
%D 2025
%X Essential tremor (ET) is a progressive disorder characterized by altered network connectivity between the cerebellum, thalamus, and cortical regions. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) of the ventral intermediate nucleus (VIM) is an effective, minimally invasive treatment for ET. The impact of MRgFUS interventions on regional Gray Matter Volume (GMV) are as yet not well understood.Forty-six patients with medication-resistant ET underwent unilateral VIM-MRgFUS. Voxel-based morphometry was applied to investigate GMV changes over a time span of 6 months in the whole brain and the thalamus in particular to investigate local and distant effects.Clinically, contralateral tremor significantly decreased by 68 
%K Humans
%K Essential Tremor: therapy
%K Essential Tremor: diagnostic imaging
%K Essential Tremor: pathology
%K Female
%K Male
%K Aged
%K Ventral Thalamic Nuclei: diagnostic imaging
%K Middle Aged
%K Magnetic Resonance Imaging
%K Cerebral Cortex: diagnostic imaging
%K Cerebral Cortex: pathology
%K Gray Matter: diagnostic imaging
%K Gray Matter: pathology
%K Neural Pathways: diagnostic imaging
%K Neural Pathways: pathology
%K Cerebellum: diagnostic imaging
%K Cerebellum: pathology
%K High-Intensity Focused Ultrasound Ablation: methods
%K Thalamus: diagnostic imaging
%K Thalamus: pathology
%K Essential tremor (Other)
%K MRgFUS (Other)
%K Structural changes (Other)
%K VBM (Other)
%K VIM (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39913957
%R 10.1016/j.parkreldis.2025.107318
%U https://pub.dzne.de/record/276825