TY  - JOUR
AU  - Krauss, Jonas
AU  - Upadhyay, Neeraj
AU  - Purrer, Veronika
AU  - Borger, Valeri
AU  - Daamen, Marcel
AU  - Schmitt, Angelika
AU  - Schmeel, Carsten
AU  - Radbruch, Alexander
AU  - Wüllner, Ullrich
AU  - Boecker, Henning
TI  - Beyond the cerebello-thalamo-cortical tract: Remote structural changes after VIM-MRgFUS in essential tremor.
JO  - Parkinsonism & related disorders
VL  - 132
SN  - 1353-8020
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2025-00338
SP  - 107318
PY  - 2025
AB  - Essential tremor (ET) is a progressive disorder characterized by altered network connectivity between the cerebellum, thalamus, and cortical regions. Magnetic Resonance-guided Focused Ultrasound (MRgFUS) of the ventral intermediate nucleus (VIM) is an effective, minimally invasive treatment for ET. The impact of MRgFUS interventions on regional Gray Matter Volume (GMV) are as yet not well understood.Forty-six patients with medication-resistant ET underwent unilateral VIM-MRgFUS. Voxel-based morphometry was applied to investigate GMV changes over a time span of 6 months in the whole brain and the thalamus in particular to investigate local and distant effects.Clinically, contralateral tremor significantly decreased by 68 
KW  - Humans
KW  - Essential Tremor: therapy
KW  - Essential Tremor: diagnostic imaging
KW  - Essential Tremor: pathology
KW  - Female
KW  - Male
KW  - Aged
KW  - Ventral Thalamic Nuclei: diagnostic imaging
KW  - Middle Aged
KW  - Magnetic Resonance Imaging
KW  - Cerebral Cortex: diagnostic imaging
KW  - Cerebral Cortex: pathology
KW  - Gray Matter: diagnostic imaging
KW  - Gray Matter: pathology
KW  - Neural Pathways: diagnostic imaging
KW  - Neural Pathways: pathology
KW  - Cerebellum: diagnostic imaging
KW  - Cerebellum: pathology
KW  - High-Intensity Focused Ultrasound Ablation: methods
KW  - Thalamus: diagnostic imaging
KW  - Thalamus: pathology
KW  - Essential tremor (Other)
KW  - MRgFUS (Other)
KW  - Structural changes (Other)
KW  - VBM (Other)
KW  - VIM (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:39913957
DO  - DOI:10.1016/j.parkreldis.2025.107318
UR  - https://pub.dzne.de/record/276825
ER  -