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@ARTICLE{Krauss:276825,
      author       = {Krauss, Jonas and Upadhyay, Neeraj and Purrer, Veronika and
                      Borger, Valeri and Daamen, Marcel and Schmitt, Angelika and
                      Schmeel, Carsten and Radbruch, Alexander and Wüllner,
                      Ullrich and Boecker, Henning},
      title        = {{B}eyond the cerebello-thalamo-cortical tract: {R}emote
                      structural changes after {VIM}-{MR}g{FUS} in essential
                      tremor.},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {132},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2025-00338},
      pages        = {107318},
      year         = {2025},
      abstract     = {Essential tremor (ET) is a progressive disorder
                      characterized by altered network connectivity between the
                      cerebellum, thalamus, and cortical regions. Magnetic
                      Resonance-guided Focused Ultrasound (MRgFUS) of the ventral
                      intermediate nucleus (VIM) is an effective, minimally
                      invasive treatment for ET. The impact of MRgFUS
                      interventions on regional Gray Matter Volume (GMV) are as
                      yet not well understood.Forty-six patients with
                      medication-resistant ET underwent unilateral VIM-MRgFUS.
                      Voxel-based morphometry was applied to investigate GMV
                      changes over a time span of 6 months in the whole brain and
                      the thalamus in particular to investigate local and distant
                      effects.Clinically, contralateral tremor significantly
                      decreased by 68 $\%$ at 6 months following MRgFUS. In
                      addition to local GMV decreases in thalamic nuclei (VIM,
                      ventral lateral posterior, centromedian thalamus and
                      pulvinar), VBM revealed remote GMV decreases in the
                      ipsilesional insula and the anterior cingulate cortex as
                      well as the contralesional middle occipital gyrus. Increased
                      GMV was found in the right superior and middle temporal
                      gyrus, as well as in the left inferior temporal gyrus. There
                      was no significant correlation between regional GMV declines
                      and tremor improvement. However, temporal volume increases
                      were associated with improved motor-related functional
                      abilities and quality of life outcomes.Our findings
                      implicate distributed structural changes following
                      unilateral VIM-MRgFUS. Structural losses could reflect
                      Wallerian degeneration of VIM output neurons or plasticity
                      due to decreased sensory input following tremor
                      improvement.},
      keywords     = {Humans / Essential Tremor: therapy / Essential Tremor:
                      diagnostic imaging / Essential Tremor: pathology / Female /
                      Male / Aged / Ventral Thalamic Nuclei: diagnostic imaging /
                      Middle Aged / Magnetic Resonance Imaging / Cerebral Cortex:
                      diagnostic imaging / Cerebral Cortex: pathology / Gray
                      Matter: diagnostic imaging / Gray Matter: pathology / Neural
                      Pathways: diagnostic imaging / Neural Pathways: pathology /
                      Cerebellum: diagnostic imaging / Cerebellum: pathology /
                      High-Intensity Focused Ultrasound Ablation: methods /
                      Thalamus: diagnostic imaging / Thalamus: pathology /
                      Essential tremor (Other) / MRgFUS (Other) / Structural
                      changes (Other) / VBM (Other) / VIM (Other)},
      cin          = {AG Boecker / Clinical Research (Bonn) / AG Radbruch / AG
                      Wüllner},
      ddc          = {610},
      cid          = {I:(DE-2719)1011202 / I:(DE-2719)1011001 /
                      I:(DE-2719)5000075 / I:(DE-2719)1011302},
      pnm          = {353 - Clinical and Health Care Research (POF4-353)},
      pid          = {G:(DE-HGF)POF4-353},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39913957},
      doi          = {10.1016/j.parkreldis.2025.107318},
      url          = {https://pub.dzne.de/record/276825},
}