%0 Journal Article
%A Winkelmeier, Laurens
%A Kniep, Helge
%A Thomalla, Götz
%A Bendszus, Martin
%A Subtil, Fabien
%A Bonekamp, Susanne
%A Aamodt, Anne Hege
%A Fuentes, Blanca
%A Gizewski, Elke R
%A Hill, Michael D
%A Krajina, Antonin
%A Pierot, Laurent
%A Simonsen, Claus Z
%A Zeleňák, Kamil
%A Blauenfeldt, Rolf A
%A Cheng, Bastian
%A Denis, Angélique
%A Deutschmann, Hannes
%A Dorn, Franziska
%A Gellissen, Susanne
%A Gerber, Johannes C
%A Goyal, Mayank
%A Haring, Jozef
%A Herweh, Christian
%A Hopf-Jensen, Silke
%A Hua, Vi Tuan
%A Jensen, Märit
%A Kastrup, Andreas
%A Keil, Christiane Fee
%A Klepanec, Andrej
%A Kurča, Egon
%A Mikkelsen, Ronni
%A Möhlenbruch, Markus
%A Müller-Hülsbeck, Stefan
%A Münnich, Nico
%A Pagano, Paolo
%A Papanagiotou, Panagiotis
%A Petzold, Gabor C
%A Pham, Mirko
%A Puetz, Volker
%A Raupach, Jan
%A Reimann, Gernot
%A Ringleb, Peter Arthur
%A Schell, Maximilian
%A Schlemm, Eckhard
%A Schönenberger, Silvia
%A Tennøe, Bjørn
%A Ulfert, Christian
%A Vališ, Kateřina
%A Vítková, Eva
%A Vollherbst, Dominik F
%A Wick, Wolfgang
%A Fiehler, Jens
%A Flottmann, Fabian
%T Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial.
%J Radiology
%V 314
%N 2
%@ 0033-8419
%C Oak Brook, Ill.
%I Soc.
%M DZNE-2025-00377
%P e242401
%D 2025
%X Background Randomized clinical trials have demonstrated that endovascular thrombectomy reduces functional disability in patients with large ischemic stroke; arterial collateral status might be used to select these patients for endovascular thrombectomy. Purpose To investigate whether arterial collateral status modifies the treatment effect of endovascular thrombectomy in patients with large ischemic stroke. Materials and Methods The Efficacy and Safety of Thrombectomy in Stroke with Extended Lesion and Extended Time Window (TENSION) trial was a prospective, multicenter, randomized study investigating participants with acute large ischemic stroke due to anterior circulation large-vessel occlusion. Participants with an Alberta Stroke Program Early CT Score of 3-5 were enrolled at 41 participating centers between July 2018 and February 2023. Participants were randomly assigned to undergo either endovascular thrombectomy with best medical treatment or best medical treatment alone within 12 hours from stroke onset. Collateral status was graded on pretreatment single-phase CT angiography (CTA) images using the Tan score and dichotomized into poor (grade, 0-1) or good (grade, 2-3) based on the extent of collateral supply filling the affected middle cerebral artery territory. The primary outcome was the shift on the 90-day modified Rankin Scale (mRS). Results Of 253 randomized patients, 201 with pretreatment CTA were included (median age, 74 years; IQR, 66-80 years; 103 [51.2
%K Humans
%K Female
%K Male
%K Endovascular Procedures: methods
%K Ischemic Stroke: diagnostic imaging
%K Ischemic Stroke: surgery
%K Ischemic Stroke: therapy
%K Aged
%K Thrombectomy: methods
%K Collateral Circulation
%K Prospective Studies
%K Computed Tomography Angiography: methods
%K Treatment Outcome
%K Middle Aged
%K Aged, 80 and over
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39998372
%R 10.1148/radiol.242401
%U https://pub.dzne.de/record/277314