TY  - JOUR
AU  - Winkelmeier, Laurens
AU  - Kniep, Helge
AU  - Thomalla, Götz
AU  - Bendszus, Martin
AU  - Subtil, Fabien
AU  - Bonekamp, Susanne
AU  - Aamodt, Anne Hege
AU  - Fuentes, Blanca
AU  - Gizewski, Elke R
AU  - Hill, Michael D
AU  - Krajina, Antonin
AU  - Pierot, Laurent
AU  - Simonsen, Claus Z
AU  - Zeleňák, Kamil
AU  - Blauenfeldt, Rolf A
AU  - Cheng, Bastian
AU  - Denis, Angélique
AU  - Deutschmann, Hannes
AU  - Dorn, Franziska
AU  - Gellissen, Susanne
AU  - Gerber, Johannes C
AU  - Goyal, Mayank
AU  - Haring, Jozef
AU  - Herweh, Christian
AU  - Hopf-Jensen, Silke
AU  - Hua, Vi Tuan
AU  - Jensen, Märit
AU  - Kastrup, Andreas
AU  - Keil, Christiane Fee
AU  - Klepanec, Andrej
AU  - Kurča, Egon
AU  - Mikkelsen, Ronni
AU  - Möhlenbruch, Markus
AU  - Müller-Hülsbeck, Stefan
AU  - Münnich, Nico
AU  - Pagano, Paolo
AU  - Papanagiotou, Panagiotis
AU  - Petzold, Gabor C
AU  - Pham, Mirko
AU  - Puetz, Volker
AU  - Raupach, Jan
AU  - Reimann, Gernot
AU  - Ringleb, Peter Arthur
AU  - Schell, Maximilian
AU  - Schlemm, Eckhard
AU  - Schönenberger, Silvia
AU  - Tennøe, Bjørn
AU  - Ulfert, Christian
AU  - Vališ, Kateřina
AU  - Vítková, Eva
AU  - Vollherbst, Dominik F
AU  - Wick, Wolfgang
AU  - Fiehler, Jens
AU  - Flottmann, Fabian
TI  - Arterial Collaterals and Endovascular Treatment Effect in Acute Ischemic Stroke with Large Infarct: A Secondary Analysis of the TENSION Trial.
JO  - Radiology
VL  - 314
IS  - 2
SN  - 0033-8419
CY  - Oak Brook, Ill.
PB  - Soc.
M1  - DZNE-2025-00377
SP  - e242401
PY  - 2025
AB  - Background Randomized clinical trials have demonstrated that endovascular thrombectomy reduces functional disability in patients with large ischemic stroke; arterial collateral status might be used to select these patients for endovascular thrombectomy. Purpose To investigate whether arterial collateral status modifies the treatment effect of endovascular thrombectomy in patients with large ischemic stroke. Materials and Methods The Efficacy and Safety of Thrombectomy in Stroke with Extended Lesion and Extended Time Window (TENSION) trial was a prospective, multicenter, randomized study investigating participants with acute large ischemic stroke due to anterior circulation large-vessel occlusion. Participants with an Alberta Stroke Program Early CT Score of 3-5 were enrolled at 41 participating centers between July 2018 and February 2023. Participants were randomly assigned to undergo either endovascular thrombectomy with best medical treatment or best medical treatment alone within 12 hours from stroke onset. Collateral status was graded on pretreatment single-phase CT angiography (CTA) images using the Tan score and dichotomized into poor (grade, 0-1) or good (grade, 2-3) based on the extent of collateral supply filling the affected middle cerebral artery territory. The primary outcome was the shift on the 90-day modified Rankin Scale (mRS). Results Of 253 randomized patients, 201 with pretreatment CTA were included (median age, 74 years; IQR, 66-80 years; 103 [51.2
KW  - Humans
KW  - Female
KW  - Male
KW  - Endovascular Procedures: methods
KW  - Ischemic Stroke: diagnostic imaging
KW  - Ischemic Stroke: surgery
KW  - Ischemic Stroke: therapy
KW  - Aged
KW  - Thrombectomy: methods
KW  - Collateral Circulation
KW  - Prospective Studies
KW  - Computed Tomography Angiography: methods
KW  - Treatment Outcome
KW  - Middle Aged
KW  - Aged, 80 and over
LB  - PUB:(DE-HGF)16
C6  - pmid:39998372
DO  - DOI:10.1148/radiol.242401
UR  - https://pub.dzne.de/record/277314
ER  -