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@ARTICLE{Qu:277324,
      author       = {Qu, Tao},
      title        = {{T}he effects of amyloidosis and aging on glutamatergic and
                      {GABA}ergic synapses, and interneurons in the barrel cortex
                      and non-neocortical brain regions.},
      journal      = {Frontiers in neuroanatomy},
      volume       = {19},
      issn         = {1662-5129},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {DZNE-2025-00386},
      pages        = {1526962},
      year         = {2025},
      abstract     = {Previous studies on changes in the distribution of
                      GABAergic interneurons and excitation/inhibition (E/I)
                      balance in Alzheimer's disease (AD) and aging were mainly
                      conducted in the neocortex and hippocampus. However, the
                      limbic system is the primary and crucial location for AD
                      progression. Therefore, in this study, we utilized AD and
                      aging mouse models to investigate the E/I balance and the
                      distribution of parvalbumin (PV)- and somatostatin
                      (SST)-expressing cells in S1BF (barrel field of primary
                      somatosensory cortex, barrel cortex), CA1 hippocampal area
                      and brain regions beyond the neocortex and hippocampus,
                      including retrosplenial cortex (RSC, which is composed of
                      RSG and RSA), piriform cortex (Pir), amygdala (BMA), and
                      hypothalamus (DM). We discovered that amyloidosis may
                      disrupt the alignment of excitatory pre- and postsynaptic
                      quantities. Amyloidosis reduces the quantity of synapses and
                      SST cells, but does not impact the counts of PV cells. By
                      contrast, aging is linked to a decline in synapses, I/E
                      ratios, SST and PV cells. Amyloidosis affects the S1BF and
                      BMA, while aging may harm all studied regions, including the
                      S1BF, RSC, hippocampus, Pir, BMA, and DM. Aging mostly
                      affects synapses and I/E ratios in Pir, BMA, and DM, and PV
                      and SST interneurons in the hippocampus.},
      keywords     = {AD (Other) / PV (Other) / SST (Other) / aging (Other) /
                      barrel cortex (Other) / non-neocortical brain regions
                      (Other)},
      cin          = {AG Dityatev},
      ddc          = {610},
      cid          = {I:(DE-2719)1310007},
      pnm          = {351 - Brain Function (POF4-351)},
      pid          = {G:(DE-HGF)POF4-351},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40012738},
      pmc          = {pmc:PMC11863279},
      doi          = {10.3389/fnana.2025.1526962},
      url          = {https://pub.dzne.de/record/277324},
}