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000277423 0247_ $$2ISSN$$a1432-1459
000277423 037__ $$aDZNE-2025-00406
000277423 041__ $$aEnglish
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000277423 1001_ $$0P:(DE-2719)2812633$$aLudolph, Albert$$b0$$eFirst author
000277423 245__ $$aThe deltoid muscle and the pattern of paresis in ALS.
000277423 260__ $$a[Darmstadt]$$bSteinkopff$$c2025
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000277423 520__ $$aThere is neuroanatomical and clinical evidence that the corticospinal tract governs the patterns of pareses in sporadic ALS. These patterns are mirrored by phylogenetically young monosynaptic corticomotor neuronal connections. It is well known that, clinically, dysfunction of the deltoid muscle contributes considerably to the early disability of the ALS patient. In this study, we prospectively compared the degree of pareses of the deltoid muscle with the triceps and biceps brachii in N = 71 patients (426 muscles). We could show that the extent of involvement of the deltoid muscle early in the disease process resembles that of the biceps rather than the triceps brachii. This pattern is consistent with functional data of the corticospinal monosynaptic connectivity of all three muscles.
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000277423 650_7 $$2Other$$aAmyotrophic lateral sclerosis
000277423 650_7 $$2Other$$aBiceps
000277423 650_7 $$2Other$$aCorticomotorneuronal
000277423 650_7 $$2Other$$aDeltoid
000277423 650_7 $$2Other$$aMonosynpatic
000277423 650_7 $$2Other$$aPattern of paresis
000277423 650_2 $$2MeSH$$aHumans
000277423 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: physiopathology
000277423 650_2 $$2MeSH$$aAmyotrophic Lateral Sclerosis: complications
000277423 650_2 $$2MeSH$$aDeltoid Muscle: physiopathology
000277423 650_2 $$2MeSH$$aDeltoid Muscle: pathology
000277423 650_2 $$2MeSH$$aMale
000277423 650_2 $$2MeSH$$aFemale
000277423 650_2 $$2MeSH$$aMiddle Aged
000277423 650_2 $$2MeSH$$aAged
000277423 650_2 $$2MeSH$$aParesis: etiology
000277423 650_2 $$2MeSH$$aParesis: physiopathology
000277423 650_2 $$2MeSH$$aAdult
000277423 650_2 $$2MeSH$$aProspective Studies
000277423 650_2 $$2MeSH$$aMuscle, Skeletal: physiopathology
000277423 650_2 $$2MeSH$$aPyramidal Tracts: physiopathology
000277423 650_2 $$2MeSH$$aPyramidal Tracts: pathology
000277423 650_2 $$2MeSH$$aElectromyography
000277423 650_2 $$2MeSH$$aAged, 80 and over
000277423 7001_ $$0P:(DE-2719)9001084$$aKlose, Veronika$$b1$$udzne
000277423 7001_ $$aDreyhaupt, Jens$$b2
000277423 7001_ $$aDel Tredici, Kelly$$b3
000277423 7001_ $$aBraak, Heiko$$b4
000277423 773__ $$0PERI:(DE-600)1421299-7$$a10.1007/s00415-025-12949-w$$gVol. 272, no. 3, p. 253$$n3$$p253$$tJournal of neurology$$v272$$x0367-004X$$y2025
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