TY  - JOUR
AU  - Ludolph, Albert
AU  - Klose, Veronika
AU  - Dreyhaupt, Jens
AU  - Del Tredici, Kelly
AU  - Braak, Heiko
TI  - The deltoid muscle and the pattern of paresis in ALS.
JO  - Journal of neurology
VL  - 272
IS  - 3
SN  - 0367-004X
CY  - [Darmstadt]
PB  - Steinkopff
M1  - DZNE-2025-00406
SP  - 253
PY  - 2025
AB  - There is neuroanatomical and clinical evidence that the corticospinal tract governs the patterns of pareses in sporadic ALS. These patterns are mirrored by phylogenetically young monosynaptic corticomotor neuronal connections. It is well known that, clinically, dysfunction of the deltoid muscle contributes considerably to the early disability of the ALS patient. In this study, we prospectively compared the degree of pareses of the deltoid muscle with the triceps and biceps brachii in N = 71 patients (426 muscles). We could show that the extent of involvement of the deltoid muscle early in the disease process resembles that of the biceps rather than the triceps brachii. This pattern is consistent with functional data of the corticospinal monosynaptic connectivity of all three muscles.
KW  - Humans
KW  - Amyotrophic Lateral Sclerosis: physiopathology
KW  - Amyotrophic Lateral Sclerosis: complications
KW  - Deltoid Muscle: physiopathology
KW  - Deltoid Muscle: pathology
KW  - Male
KW  - Female
KW  - Middle Aged
KW  - Aged
KW  - Paresis: etiology
KW  - Paresis: physiopathology
KW  - Adult
KW  - Prospective Studies
KW  - Muscle, Skeletal: physiopathology
KW  - Pyramidal Tracts: physiopathology
KW  - Pyramidal Tracts: pathology
KW  - Electromyography
KW  - Aged, 80 and over
KW  - Amyotrophic lateral sclerosis (Other)
KW  - Biceps (Other)
KW  - Corticomotorneuronal (Other)
KW  - Deltoid (Other)
KW  - Monosynpatic (Other)
KW  - Pattern of paresis (Other)
LB  - PUB:(DE-HGF)16
C6  - pmid:40047927
C2  - pmc:PMC11885358
DO  - DOI:10.1007/s00415-025-12949-w
UR  - https://pub.dzne.de/record/277423
ER  -