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001     277423
005     20250320091334.0
024 7 _ |a 10.1007/s00415-025-12949-w
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024 7 _ |a pmc:PMC11885358
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024 7 _ |a 0367-004X
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024 7 _ |a 0012-1037
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024 7 _ |a 0340-5354
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024 7 _ |a 1432-1459
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037 _ _ |a DZNE-2025-00406
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Ludolph, Albert
|0 P:(DE-2719)2812633
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245 _ _ |a The deltoid muscle and the pattern of paresis in ALS.
260 _ _ |a [Darmstadt]
|c 2025
|b Steinkopff
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520 _ _ |a There is neuroanatomical and clinical evidence that the corticospinal tract governs the patterns of pareses in sporadic ALS. These patterns are mirrored by phylogenetically young monosynaptic corticomotor neuronal connections. It is well known that, clinically, dysfunction of the deltoid muscle contributes considerably to the early disability of the ALS patient. In this study, we prospectively compared the degree of pareses of the deltoid muscle with the triceps and biceps brachii in N = 71 patients (426 muscles). We could show that the extent of involvement of the deltoid muscle early in the disease process resembles that of the biceps rather than the triceps brachii. This pattern is consistent with functional data of the corticospinal monosynaptic connectivity of all three muscles.
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650 _ 7 |a Amyotrophic lateral sclerosis
|2 Other
650 _ 7 |a Biceps
|2 Other
650 _ 7 |a Corticomotorneuronal
|2 Other
650 _ 7 |a Deltoid
|2 Other
650 _ 7 |a Monosynpatic
|2 Other
650 _ 7 |a Pattern of paresis
|2 Other
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: physiopathology
|2 MeSH
650 _ 2 |a Amyotrophic Lateral Sclerosis: complications
|2 MeSH
650 _ 2 |a Deltoid Muscle: physiopathology
|2 MeSH
650 _ 2 |a Deltoid Muscle: pathology
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Paresis: etiology
|2 MeSH
650 _ 2 |a Paresis: physiopathology
|2 MeSH
650 _ 2 |a Adult
|2 MeSH
650 _ 2 |a Prospective Studies
|2 MeSH
650 _ 2 |a Muscle, Skeletal: physiopathology
|2 MeSH
650 _ 2 |a Pyramidal Tracts: physiopathology
|2 MeSH
650 _ 2 |a Pyramidal Tracts: pathology
|2 MeSH
650 _ 2 |a Electromyography
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
700 1 _ |a Klose, Veronika
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700 1 _ |a Dreyhaupt, Jens
|b 2
700 1 _ |a Del Tredici, Kelly
|b 3
700 1 _ |a Braak, Heiko
|b 4
773 _ _ |a 10.1007/s00415-025-12949-w
|g Vol. 272, no. 3, p. 253
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|n 3
|p 253
|t Journal of neurology
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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