% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ehlers:277424,
      author       = {Ehlers, Greta and Tödtmann, Annika Marie and Holsten, Lisa
                      and Willers, Maike and Heckmann, Julia and Schöning,
                      Jennifer and Richter, Maximilian and Heinemann, Anna Sophie
                      and Pirr, Sabine and Heinz, Alexander and Dopfer, Christian
                      and Händler, Kristian and Becker, Matthias and Büchel,
                      Johanna and Wöckel, Achim and von Kaisenberg, Constantin
                      and Hansen, Gesine and Hiller, Karsten and Schultze, Joachim
                      L and Härtel, Christoph and Kastenmüller, Wolfgang and
                      Vaeth, Martin and Ulas, Thomas and Viemann, Dorothee},
      title        = {{O}xidative phosphorylation is a key feature of neonatal
                      monocyte immunometabolism promoting myeloid differentiation
                      after birth.},
      journal      = {Nature Communications},
      volume       = {16},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Springer Nature},
      reportid     = {DZNE-2025-00407},
      pages        = {2239},
      year         = {2025},
      abstract     = {Neonates primarily rely on innate immune defense, yet their
                      inflammatory responses are usually restricted compared to
                      adults. This is controversially interpreted as a sign of
                      immaturity or essential programming, increasing or
                      decreasing the risk of sepsis, respectively. Here, combined
                      transcriptomic, metabolic, and immunological studies in
                      monocytes of healthy individuals reveal an inverse
                      ontogenetic shift in metabolic pathway activities with
                      increasing age. Neonatal monocytes are characterized by
                      enhanced oxidative phosphorylation supporting ongoing
                      myeloid differentiation. This phenotype is gradually
                      replaced during early childhood by increasing glycolytic
                      activity fueling the inflammatory responsiveness. Microbial
                      stimulation shifts neonatal monocytes to an adult-like
                      metabolism, whereas ketogenic diet in adults mimicking
                      neonatal ketosis cannot revive a neonate-like metabolism.
                      Our findings disclose hallmarks of innate immunometabolism
                      during healthy postnatal immune adaptation and suggest that
                      premature activation of glycolysis in neonates might
                      increase their risk of sepsis by impairing myeloid
                      differentiation and promoting hyperinflammation.},
      keywords     = {Oxidative Phosphorylation / Humans / Monocytes: immunology
                      / Monocytes: metabolism / Infant, Newborn / Cell
                      Differentiation: immunology / Glycolysis / Myeloid Cells:
                      metabolism / Myeloid Cells: immunology / Adult / Immunity,
                      Innate / Female / Infant / Male / Child, Preschool / Child /
                      Diet, Ketogenic / Inflammation: metabolism / Inflammation:
                      immunology / Sepsis: immunology / Sepsis: metabolism /
                      Adolescent / Transcriptome},
      cin          = {AG Schultze / AG Becker / PRECISE},
      ddc          = {500},
      cid          = {I:(DE-2719)1013038 / I:(DE-2719)5000079 /
                      I:(DE-2719)1013031},
      pnm          = {354 - Disease Prevention and Healthy Aging (POF4-354) / 352
                      - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-354 / G:(DE-HGF)POF4-352},
      experiment   = {EXP:(DE-2719)PRECISE-20190321},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:40050264},
      pmc          = {pmc:PMC11885822},
      doi          = {10.1038/s41467-025-57357-w},
      url          = {https://pub.dzne.de/record/277424},
}