%0 Journal Article
%A Wiels, Wietse A
%A Oomens, Julie E
%A Engelborghs, Sebastiaan
%A Baeken, Chris
%A von Arnim, Christine A F
%A Boada, Mercè
%A Didic, Mira
%A Dubois, Bruno
%A Fladby, Tormod
%A van der Flier, Wiesje M
%A Frisoni, Giovanni B
%A Fröhlich, Lutz
%A Gill, Kiran Dip
%A Grimmer, Timo
%A Hildebrandt, Helmut
%A Hort, Jakub
%A Itoh, Yoshiaki
%A Iwatsubo, Takeshi
%A Klimkowicz-Mrowiec, Aleksandra
%A Lee, Dong Young
%A Lleó, Alberto
%A Martinez-Lage, Pablo
%A de Mendonça, Alexandre
%A Meyer, Philipp T
%A Kapaki, Elisabeth N
%A Parchi, Piero
%A Pardini, Matteo
%A Parnetti, Lucilla
%A Popp, Julius
%A Rami, Lorena
%A Reiman, Eric M
%A Rinne, Juha O
%A Rodrigue, Karen M
%A Sánchez-Juan, Pascual
%A Santana, Isabel
%A Sarazin, Marie
%A Scarmeas, Nikolaos
%A Skoog, Ingmar
%A Snyder, Peter J
%A Sperling, Reisa A
%A Villeneuve, Sylvia
%A Wallin, Anders
%A Wiltfang, Jens
%A Zetterberg, Henrik
%A Ossenkoppele, Rik
%A Verhey, Frans R J
%A Vos, Stephanie J B
%A Visser, Pieter Jelle
%A Jansen, Willemijn J
%A Alcolea, Daniel
%A Altomare, Daniele
%A Baiardi, Simone
%A Baldeiras, Ines
%A Bateman, Randall J
%A Blennow, Kaj
%A Bottlaender, Michel
%A den Braber, Anouk
%A van Buchem, Mark A
%A Byun, Min Soo
%A Cerman, Jirí
%A Chen, Kewei
%A Chipi, Elena
%A Day, Gregory S
%A Drzezga, Alexander
%A Eckerström, Marie
%A Ekblad, Laura L
%A Epelbaum, Stéphane
%A Förster, Stefan
%A Fortea, Juan
%A Freund-Levi, Yvonne
%A Frings, Lars
%A Guedj, Eric
%A Hausner, Lucrezia
%A Hellwig, Sabine
%A Huey, Edward D
%A Jiménez-Bonilla, Julio F
%A Johnson, Keith A
%A Juaristi, Ane Iriondo
%A Kandimalla, Ramesh
%A Paraskevas, George
%A Kern, Silke
%A Kirsebom, Bjørn-Eivind S
%A Kornhuber, Johannes
%A Lagarde, Julien
%A Landau, Susan M
%A Legdeur, Nienke
%A Llibre Guerra, Jorge J
%A Maserejian, Nancy N
%A Marquié, Marta
%A Minatani, Shinobu
%A Morbelli, Silvia Daniela
%A Mroczko, Barbara
%A Ntanasi, Eva
%A de Oliveira, Catarina Resende
%A Olivieri, Pauline
%A Orellana, Adelina
%A Perrin, Richard J
%A Peters, Oliver
%A Prabhakar, Sudesh
%A Ramakers, Inez H
%A Rodríguez-Rodriguez, Eloy
%A Ruiz, Agustín
%A Rüther, Eckart
%A Selnes, Per
%A Silva, Dina
%A Soininen, Hilkka
%A Spiru, Luiza
%A Takeda, Akitoshi
%A Teichmann, Marc
%A Tijms, Betty M
%A Teunissen, Charlotte E
%A Thompson, Loisa I
%A Vogelgsangs, Jonathan
%A Vöglein, Jonathan
%A Waldemar, Gunhild
%A Wallin, Åsa K
%A Yannakoulia, Mary
%A Yi, Dahyun
%A Zettergren, Anna
%T Depressive Symptoms and Amyloid Pathology.
%J JAMA psychiatry
%V 82
%N 3
%@ 2168-622X
%C Chicago, Ill.
%I AMA
%M DZNE-2025-00409
%P 296 - 310
%D 2025
%X Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.To examine the association between depressive symptoms and amyloid pathology and its dependency on age, sex, education, and APOE genotype in older individuals without dementia.Cross-sectional analyses were performed using data from the Amyloid Biomarker Study data pooling initiative. Data from 49 research, population-based, and memory clinic studies were pooled and harmonized. The Amyloid Biomarker Study has been collecting data since 2012 and data collection is ongoing. At the time of analysis, 95 centers were included in the Amyloid Biomarker Study. The study included 9746 individuals with normal cognition (NC) and 3023 participants with mild cognitive impairment (MCI) aged between 34 and 100 years for whom data on amyloid biomarkers, presence of depressive symptoms, and age were available. Data were analyzed from December 2022 to February 2024.Amyloid-β1-42 levels in cerebrospinal fluid or amyloid positron emission tomography scans were used to determine presence or absence of amyloid pathology. Presence of depressive symptoms was determined on the basis of validated depression rating scale scores, evidence of a current clinical diagnosis of depression, or self-reported depressive symptoms.In individuals with NC (mean [SD] age, 68.6 [8.9] years; 5664 [58.2
%K Humans
%K Female
%K Male
%K Aged
%K Depression
%K Middle Aged
%K Cross-Sectional Studies
%K Cognitive Dysfunction
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Amyloid beta-Peptides: metabolism
%K Positron-Emission Tomography
%K Aged, 80 and over
%K Adult
%K Biomarkers: cerebrospinal fluid
%K Peptide Fragments: cerebrospinal fluid
%K Apolipoprotein E4: genetics
%K Age Factors
%K Amyloid beta-Peptides (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K Apolipoprotein E4 (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39841452
%2 pmc:PMC11883504
%R 10.1001/jamapsychiatry.2024.4305
%U https://pub.dzne.de/record/277426