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000277427 041__ $$aEnglish
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000277427 1001_ $$0P:(DE-2719)9003407$$aLonkar, Neha$$b0$$eFirst author$$udzne
000277427 245__ $$aNeuroinflammation and immunometabolism in neurodegenerative diseases.
000277427 260__ $$aLondon$$bLippincott Williams & Wilkins$$c2025
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000277427 520__ $$aImmunometabolism is an emerging field of research investigating the ability of immune cells to modulate their metabolic activity for optimal function. While this has been extensively examined in peripheral immune cells like macrophages, only recently have these studies been extended to assess the immunometabolic activity of microglia, the innate immune cells of the brain.Microglia are highly metabolically flexible and can utilize different nutrients for their diverse functions. Like other immune cells, they undergo metabolic reprogramming on immune stimulation and in inflammatory, neurodegenerative conditions such as Alzheimer's disease (AD). In recent years, researchers have looked at the intricate mechanisms that modulate microglial activity and have uncovered key links between altered metabolism, neuroinflammation, and the involvement of disease-associated risk genes.This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling novel targets for therapeutic intervention.
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000277427 650_2 $$2MeSH$$aHumans
000277427 650_2 $$2MeSH$$aMicroglia: metabolism
000277427 650_2 $$2MeSH$$aMicroglia: immunology
000277427 650_2 $$2MeSH$$aNeurodegenerative Diseases: immunology
000277427 650_2 $$2MeSH$$aNeurodegenerative Diseases: metabolism
000277427 650_2 $$2MeSH$$aNeuroinflammatory Diseases: immunology
000277427 650_2 $$2MeSH$$aNeuroinflammatory Diseases: metabolism
000277427 650_2 $$2MeSH$$aAnimals
000277427 650_2 $$2MeSH$$aAlzheimer Disease: immunology
000277427 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000277427 650_2 $$2MeSH$$aBrain: metabolism
000277427 650_2 $$2MeSH$$aBrain: immunology
000277427 7001_ $$0P:(DE-2719)2000062$$aLatz, Eicke$$b1$$udzne
000277427 7001_ $$0P:(DE-2719)2811671$$aMcManus, Róisín M$$b2$$eLast author$$udzne
000277427 773__ $$0PERI:(DE-600)2026967-5$$a10.1097/WCO.0000000000001356$$gVol. 38, no. 2, p. 163 - 171$$n2$$p163 - 171$$tCurrent opinion in neurology$$v38$$x1350-7540$$y2025
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