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@ARTICLE{Lonkar:277427,
      author       = {Lonkar, Neha and Latz, Eicke and McManus, Róisín M},
      title        = {{N}euroinflammation and immunometabolism in
                      neurodegenerative diseases.},
      journal      = {Current opinion in neurology},
      volume       = {38},
      number       = {2},
      issn         = {1350-7540},
      address      = {London},
      publisher    = {Lippincott Williams $\&$ Wilkins},
      reportid     = {DZNE-2025-00410},
      pages        = {163 - 171},
      year         = {2025},
      abstract     = {Immunometabolism is an emerging field of research
                      investigating the ability of immune cells to modulate their
                      metabolic activity for optimal function. While this has been
                      extensively examined in peripheral immune cells like
                      macrophages, only recently have these studies been extended
                      to assess the immunometabolic activity of microglia, the
                      innate immune cells of the brain.Microglia are highly
                      metabolically flexible and can utilize different nutrients
                      for their diverse functions. Like other immune cells, they
                      undergo metabolic reprogramming on immune stimulation and in
                      inflammatory, neurodegenerative conditions such as
                      Alzheimer's disease (AD). In recent years, researchers have
                      looked at the intricate mechanisms that modulate microglial
                      activity and have uncovered key links between altered
                      metabolism, neuroinflammation, and the involvement of
                      disease-associated risk genes.This review highlights the
                      recent studies that have significantly contributed to our
                      understanding of the metabolic dysregulation observed in
                      activated microglia in conditions such as AD, unveiling
                      novel targets for therapeutic intervention.},
      subtyp        = {Review Article},
      keywords     = {Humans / Microglia: metabolism / Microglia: immunology /
                      Neurodegenerative Diseases: immunology / Neurodegenerative
                      Diseases: metabolism / Neuroinflammatory Diseases:
                      immunology / Neuroinflammatory Diseases: metabolism /
                      Animals / Alzheimer Disease: immunology / Alzheimer Disease:
                      metabolism / Brain: metabolism / Brain: immunology},
      cin          = {AG McManus},
      ddc          = {610},
      cid          = {I:(DE-2719)1013042},
      pnm          = {352 - Disease Mechanisms (POF4-352)},
      pid          = {G:(DE-HGF)POF4-352},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:39936491},
      doi          = {10.1097/WCO.0000000000001356},
      url          = {https://pub.dzne.de/record/277427},
}