Home > Publications Database > Neuroinflammation and immunometabolism in neurodegenerative diseases. > print

001     277427
005     20250323000947.0
024 7 _ |a 10.1097/WCO.0000000000001356
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024 7 _ |a 1350-7540
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024 7 _ |a 1473-6551
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037 _ _ |a DZNE-2025-00410
041 _ _ |a English
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100 1 _ |a Lonkar, Neha
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245 _ _ |a Neuroinflammation and immunometabolism in neurodegenerative diseases.
260 _ _ |a London
|c 2025
|b Lippincott Williams & Wilkins
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520 _ _ |a Immunometabolism is an emerging field of research investigating the ability of immune cells to modulate their metabolic activity for optimal function. While this has been extensively examined in peripheral immune cells like macrophages, only recently have these studies been extended to assess the immunometabolic activity of microglia, the innate immune cells of the brain.Microglia are highly metabolically flexible and can utilize different nutrients for their diverse functions. Like other immune cells, they undergo metabolic reprogramming on immune stimulation and in inflammatory, neurodegenerative conditions such as Alzheimer's disease (AD). In recent years, researchers have looked at the intricate mechanisms that modulate microglial activity and have uncovered key links between altered metabolism, neuroinflammation, and the involvement of disease-associated risk genes.This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling novel targets for therapeutic intervention.
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650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Microglia: metabolism
|2 MeSH
650 _ 2 |a Microglia: immunology
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: immunology
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: metabolism
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: immunology
|2 MeSH
650 _ 2 |a Neuroinflammatory Diseases: metabolism
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Alzheimer Disease: immunology
|2 MeSH
650 _ 2 |a Alzheimer Disease: metabolism
|2 MeSH
650 _ 2 |a Brain: metabolism
|2 MeSH
650 _ 2 |a Brain: immunology
|2 MeSH
700 1 _ |a Latz, Eicke
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700 1 _ |a McManus, Róisín M
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773 _ _ |a 10.1097/WCO.0000000000001356
|g Vol. 38, no. 2, p. 163 - 171
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|t Current opinion in neurology
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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