%0 Journal Article
%A Quattrone, Andrea
%A Franzmeier, Nicolai
%A Levin, Johannes
%A Petzold, Gabor C
%A Spottke, Annika
%A Brosseron, Frederic
%A Falkenburger, Björn
%A Prudlo, Johannes
%A Gasser, Thomas
%A Höglinger, Günter U
%T Prospective Multicenter Evaluation of the MDS 'Suggestive of PSP' Diagnostic Criteria.
%J Movement disorders
%V 40
%N 3
%@ 0885-3185
%C New York, NY
%I Wiley
%M DZNE-2025-00448
%P 526 - 536
%D 2025
%X The recent Movement Disorders Society (MDS)-progressive supranuclear palsy (PSP) diagnostic criteria conceptualized three clinical diagnostic certainty levels: 'suggestive of PSP' for sensitive early diagnosis based on subtle clinical signs, 'possible PSP' balancing sensitivity and specificity, and 'probable PSP' highly specific for PSP pathology.The aim of this study was to prospectively validate the criteria against long-term clinical follow-up and characterize the diagnostic certainty increase over time.Patients with 'possible PSP' or 'suggestive of PSP' diagnosis and clinical follow-up were recruited in two German multicenter longitudinal observational studies (ProPSP and DescribePSP). The cumulative percentage of patients longitudinally increasing diagnostic certainty was assessed over up to 2.5 years of follow-up. The sample size per arm required to detect 30
%K Humans
%K Supranuclear Palsy, Progressive: diagnosis
%K Female
%K Male
%K Aged
%K Middle Aged
%K Longitudinal Studies
%K Prospective Studies
%K Sensitivity and Specificity
%K Aged, 80 and over
%K diagnostic criteria (Other)
%K longitudinal (Other)
%K progressive supranuclear palsy (Other)
%K suggestive of PSP (Other)
%K validation (Other)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:39797511
%2 pmc:PMC11926504
%R 10.1002/mds.30112
%U https://pub.dzne.de/record/277727